摘要
目的了解绍兴地区胆石症患者胆汁中的病原菌构成及耐药性,指导临床合理应用抗菌药物。方法对2009年1月-2010年6月住院的胆石症患者胆汁标本中分离的287株病原菌及耐药性进行分析,并对革兰阴性杆菌进行ESBLs检测。结果分离到的287株病原菌中,革兰阴性杆菌占68.64%,主要以大肠埃希菌和肺炎克雷伯菌为主,分别占27.18%和11.50%;革兰阳性球菌占28.57%,以肠球菌属为主,占全部病原菌的25.78%,其中粪肠球菌占8.71%,屎肠球菌占5.92%;真菌占2.79%;肠杆菌属对阿米卡星、亚胺培南、美罗培南、厄他培南具有较高的敏感率;肠球菌属对利奈唑胺、替考拉宁、万古霉素耐药率较低。结论绍兴地区胆石症患者胆汁病原菌感染,以革兰阴性杆菌为主,其中大肠埃希菌最多;各种病原菌对抗菌药物均有不同程度的耐药,因此加强病原菌耐药监测,对临床合理使用抗菌药物有重要的意义。
OBJECTIVE To investigate the composition of biliary pathogenic bacteria and state of drug resistance in cholelithiasis patients in Shaoxing area,to guide appropriate use of antimicrobials. METHODS A total of 287 pathogenic bacteria isolated from cholelithiasis patients bile specimen which recruited from Jan.2009 to June.2010 and state of drug resistance were analyzed.And ESBLs tests were performed in Gram-negative bacilli. RESULTS Of 287 pathogenic bacteria,Gram-negative bacilli accounted for 68.64%,predominantly E.coli and K.pneumoniae（27.18% and 11.50% respectively）.Gram-positive cocci accounted for 28.57%,most of them were enterococci,which accounted for of 25.78% in all pathogenic bacteria（Enterococcus faecalis 8.7%,excrement Enterococcus faecium 5.92%）.Fungus accounted for 2.79%.Enterobacteriaceae had a relative high sensitivity to imipenem,meropenem and etapenem;furthermore,enterococci had low drug resistance rate to linozulam,teicoplanin and vancomycin. CONCLUSION Cholelithiasis patients′ bile bacterial infection are mostly caused by Gram-negative bacilli,and the vast majority of them is E.coli.Different bacteria have variable resistance to antimicrobials,hence,it is meaningful to monitor bacterial drug resistance for clinical drug appropriate and reasonable use.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第22期4831-4833,共3页
Chinese Journal of Nosocomiology
关键词
胆石症
胆汁
病原菌
培养
耐药率
Cholelithiasis
Bile
Pathogens
Culture
Drug resistance rate
