摘要
目的检测胃癌基质金属蛋白酶-3(MMP-3)和血管内皮生长因子(VEGF)的表达,探讨MMP-3和VEGF在不同临床病理特征中的意义,以期为临床工作提供理论支持。方法本实验以140例胃癌新鲜标本作为观察组,140例正常新鲜胃黏膜组织作为对照组,采用流式细胞技术,检测两组中MMP-3和VEGF表达的关系,观察MMP-3和VEGF的表达在不同临床特征中的差别。结果胃癌中MMP-3和VEGF的表达量明显高于对照组,MMP-3和VEGF的表达与胃癌的分化程度、浸润深度及淋巴结转移密切相关。MMP-3和VEGF在胃癌中的表达呈正相关性。结论胃癌中MMP-3和VEGF高表达,参与肿瘤的发生发展,联合检测MMP-3和VEGF的表达可能对判断胃癌的预后有一定价值。
Objective To detect the expressions of MMP-3 and VEGF, and investigate their clinical char- acteristic in gastric carcinoma. Methods The study included 140 cases of gastric carcinoma as observation group, 140 cases of normal gastric mucosa as control group. The expressions of MMP-3 and VEGF were detected in two groups by FCM. We analyzed the different clinical characteristic in the observation group. Results The higher expressions of MMP-3 and VEGF were found in the observation group than that in the control group. The expressions of MMP-3 and VEGF were obviously significant in differetiation, depth and lymph metastasis. The positive correlation of MMP-3 and VEGF were found in gastric carcino- ma. Conclusion The higher expressions of MMP-3 and VEGF can promote the occurrence and develop- ment in gastric carcinoma. The combined detection of MMP-3 and VEGF may be help to predict the prog- nosis in gastric carcinoma.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2011年第10期1140-1142,共3页
Cancer Research on Prevention and Treatment
