摘要
目的运用Meta分析的方法综合评价DNA修复基因(X-ray repair cross-complementing group 1,XRCC1)的多态性与淋巴瘤发病风险的关系。方法计算机检索PubMed、EMbase、中国期刊全文数据库、维普中文科技期刊数据库、中国生物医学文献数据库,同时手工检索所有纳入文献的参考文献,收集截止到2010年2月关于XRCC1基因多态性与淋巴瘤发病风险的病例对照研究,由两名研究者独立按照纳入标准筛选文献、提取资料并交叉核对,统计分析采用RevMan5.0软件进行。结果共纳入11个病例对照研究,包括4 569例患者和5 746例对照。Meta分析结果显示:XRCC1 codon 399基因型Gln/Gln、Arg/Gln和Gln/Gln+Arg/Gln与野生型Arg/Arg相比,频率差异均无统计学意义(Gln/Gln vs.Arg/Arg:OR=1.04,95%CI[0.87,1.25];Arg/Gln vs.Arg/Arg:OR=1.26,95%CI[0.95,1.66];Gln/Gln+Arg/Gln vs.Arg/Arg:OR=1.02,95%CI[0.91,1.13]),Gln/Gln+Arg/Gln基因型则有可能增加霍奇金淋巴瘤的发病风险(OR=1.31,95%CI[1.02,1.69]),XRCC1 codon280和XRCC1 codon 194的基因多态性在患者和对照组之间的差异无统计学意义(XRCC1 codon280 His/His+Arg/His vs.Arg/Arg:OR=0.97,95%CI[0.69,1.38];XRCC1 codon 194 Trp/Trp+Arg/Trp vs.Arg/Arg:OR=1.01,95%CI[0.78,1.32])。结论 DNA修复基因XRCC1的基因多态性与非霍奇金淋巴瘤发病风险没有相关性,codon399位点的Gln/Gln+Arg/Gln基因型则有可能增加霍奇金淋巴瘤的发病风险。
Objective To evaluate the association between X-ray repair cross-complementing groupl （XRCC1） gene polymorphisms and lymphoma risk by means of Meta-analysis. Methods We searched PubMed, EMbase, Chinese National Knowledge Infrastructure, China Journal Full Text Database, Chinese Biomedical Literature Database up to Feb 2010, the references of eligible studies were searched by hand. Case-Control studies involving X-ray repair cross-complementing group1 （XRCCI） genetic polymorphism and lymphoma risk were included. Data were extracted independently by two reviewers according to designed extraction. The Cochrane Collaboration＇s RevMan 5.0 software was applied for statistical analy- ses. Results A total of 11 studies involving 4 569 patients and 5 746 controls were included. The results of Meta-analysis showed no statistical difference in the frequencies of variant genotypes and wild homozygote of XRCC1 between the Non-Hodgkin＇s lymphoma patients and controls, but Gln/Gln ＋ Arg/Gln gentype of eodon 399 may increase the risk of Hodgkin＇s lymphoma（OR = 1.31,95%CI[l. 02, 1.69]）. Conclusion The polymorphism at codon 399,194 and 280 of XRCCt are not associated with Non- Hodgkin＇s lymphoma risk but Gln/Gln ＋ Arg/Gln genotype of codon 399 may increase the risk of Hodgkin＇s lymphoma.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2011年第10期1181-1186,共6页
Cancer Research on Prevention and Treatment
