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穿蛭膏对家兔实验性骨关节炎细胞因子IL-1β和TNF-α的影响 被引量:8

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摘要 目的探讨穿蛭膏对骨关节炎模型细胞因子的影响。方法健康新西兰大白兔30只随机分为空白对照组、模型组、用药组,每组10只。除空白对照组,均用Hu lth法建立实验性骨关节炎模型。造模成功后用药组穿蛭膏右膝关节外敷,3d1次,4周后实验家兔摄取侧位X线片并采用放免法检测关节冲洗液中细胞因子IL-1β和TNF-α的含量。结果与对照组相比,模型组、用药组关节液中IL-1β的含量和TNF-α的含量明显升高(P<0.05),与模型组相比,用药组关节液中IL-1β的含量和TNF-α的含量水平下降(P<0.05)。结论穿蛭膏对骨关节炎有一定的抑制作用。
出处 《时珍国医国药》 CAS CSCD 北大核心 2011年第6期1424-1425,共2页 Lishizhen Medicine and Materia Medica Research
基金 吉林省教育厅十一五科学技术研究重点资助项目(No.[2008]260)
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