摘要
目的研究(+)-顺丁烯二酸单冰片酯在大鼠血清中的药代动力学。方法 10只SD健康大鼠灌胃给药后,测定不同时间点血清中(+)-顺丁烯二酸单冰片酯的浓度,采用PK solu 2.0(USA)动力学软件计算药动学参数。结果在大鼠血清中(+)-顺丁烯二酸单冰片酯的吸收相半衰期t1/2(abs)为(0.066±0.035 0)h、分布相半衰期t1/2α为(0.117±0.082 1)h、消除相半衰期t1/2β为(6.712±4.177)h、表观分布容积Vd为(3 954.89±844.056)L、达峰时间Tmax为(0.3±0.000 1)h、曲线下总面积AUC为(0.28±0.078 9)mg.h-1.L-1。结论 (+)-顺丁烯二酸单冰片酯的药代动力学过程符合二室模型。
Objective To study the pharmacokinetics of（＋）-bornyl monomaleate in rat serum. Methods 10 SD healthy rats were intragastric administered（＋）-bornyl monomaleate.The content of（＋）-bornyl monomaleate in rat serum at different time points was tested.Pharmacokinetic parameters were determined by PK solu 2.0（USA） software. Results The half-life of absorption,distribution and elimination was（0.066±0.035） h,（0.117±0.082） h,（6.712±4.177） h,respectively.Apparent volume of distribution（Vd） was 3 954.89±844.06 L.Time to peak（Tmax） was 0.3±0.0 h.The total area under the curve（AUC） was（0.28±0.08） mg·h-1·L-1. Conclusion The pharmacokinetic process of（＋）-bornyl monomaleate in rat serum is in accordance with the two-compartment open model.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2011年第9期2300-2301,共2页
Lishizhen Medicine and Materia Medica Research
