摘要
目的:探讨食管鳞状细胞癌中基质金属蛋白酶1(MMP-1)和血管内皮生长因子C(VEGF-C)的表达及临床意义。方法:收集医院2008-12～2011-04收治的44例食管鳞状细胞癌患者,采用免疫组织化学SP法检测MMP-1和VEGF-C,并与同期45例正常食管组织中MMP-1和VEGF-C的表达情况进行对比分析。结果:食管鳞状细胞癌组MMP-1和VEGF-C表达阳性率分别为65.9%和75.0%,正常食管组织的MMP-1和VEGF-C表达阳性率分别为11.1%和15.6%,两组间比较均有显著性差异(均P<0.05)。结论:MMP-1和VEGF-C的表达的表达在食管鳞状细胞癌的发生发展过程中发挥着重要作用,有助于食管鳞状细胞癌的临床诊断,值得临床关注。
Objective：To discuss the expression and clinical significance of MMP-1 and VEGF-C in the patients with esophageal squamous cell carcinoma.Methods： From December 2008 to April 2011 in our hospital,44 patients of esophageal squamous cell carcinoma used immunohistochemical S-P assay for MMP-1 and VEGF-C testing,with 45 cases of normal esophagus tissues expression of MMP-1 and VEGF-C to analyzed.the reaults Results： The positive expression rates of MMP-1 and VEGF-C in esophageal squamous cell carcinoma were 65.9% and 75.0%,and in the normal esophagus tissues group were 11.1% and 15.6%,there were significantly differences between two groups（all P0.05）.Conclusion： The expression of MMP-1 and VEGF-C play an important role in the development and progression of esophageal squamous cell carcinoma,therefore they are helpful to the clinical diagnosis of esophageal squamous cell carcinoma,and is worthy of clinical attention.
出处
《牡丹江医学院学报》
2011年第5期3-5,共3页
Journal of Mudanjiang Medical University
关键词
食管鳞状细胞癌
基质金属蛋白酶1
血管内皮生长因子C
Esophageal squamous cell carcinoma
Matrix metalloproteinase 1（MMP-1）
Vascular endothelial growth factor C（VEGF-C）
