摘要
目的:观察辛夷鼻炎丸对急、慢性鼻炎的临床症状体征的改善情况,对其有效性和安全性进行评价,以进一步验证药物的疗效及副作用。方法:将192例临床确诊的急、慢性鼻炎患者按单纯随机方法分为两组(试验组96例和对照组96例),试验组予以辛夷鼻炎丸口服,每次3克,每日3次,疗程14天;对照组予以鼻炎康片口服,每次5片,每日3次,疗程14天。观察用药后各项症状体征改变情况,并对其安全性进行评价。结果:(1)有效性结果表明:急性鼻炎治疗组(n=48)的临床总有效率95.83%,对照组(n=48)总有效率为95.83%,两者比较差异无统计学意义(P=1.000),其征候体征疗效比较差异有统计学意义(P=0.019),治疗组优于对照组。慢性鼻炎治疗组的总有效率为83.3%,对照组(n=48)总有效率为91.67%,两者比较差异无统计学意义(P=0.08);其征候体征疗效比较差异有统计学意义(P=0.017),治疗组优于对照组。(2)安全性结果表明:治疗组不良反应的发生率为3.13%,对照组不良反应的发生率为0.00%,两组不良反应发生率的差异无统计学意义(P=0.31)。研究中治疗组和对照组均无严重不良事件发生。结论:辛夷鼻炎丸对急、慢性鼻炎之外感风邪证疗效确切,服用方便,并且其安全性较好,可有效治疗急、慢性鼻炎。
Objective：To observe the shot（farnesol-type） rhinitis acute and chronic rhinitis of the clinical signs and symptoms to evaluate its effectiveness and safety,to further drug efficacy and side effects.Methods： The clinical diagnosis of 192 patients with acute and chronic rhinitis by simple random method was made and divided into two groups（the expenimental group cantains 96 and control group 96）,shall take oral administration,every time,3 times a day,treated for 14 days;The control group tablets,rhinitis kang 5 pieces of,3 times a day for 14 days.Observe all the signs and symptoms changegrouptak.Results：（1） Validity results show that： a -cute rhinitis treatment group（n = 48）,the total effective control of clinical 95.83%（n = 48） the total effective rate was 95.83%,both comparative difference was statistically significant（P = 1.000）,the more obvious differences 364-7 signs curative effect of statistical significance（P = 0.019）,the treatment group than in control group.total effective rate of the treatment group and control group（n = 948） Chronic rhinitis was 91.67%,both comparative difference was statistically significant（P = 0.08）;Its symptoms signs are statistically significant,effect comparative differences（P = 0.017）,the treatment group than in control group.（2） security results show that： treatment group for the incidence of aderse eents 3.13% group,the incidence of aderse eents for 0.00%,two groups of adverse reaction rate difference was statistically significant（P = 0.31）.Research in treatment group and control group was no serious adverse events.Conclusion：（Farnesol-type） rhinitis pill for acute and chronic rhinitis outside feeling wind evil card,taking convenient definite effect,and its safety is good,can effectively treat acute and chronic rhinitis.
出处
《牡丹江医学院学报》
2011年第5期9-12,共4页
Journal of Mudanjiang Medical University
关键词
辛夷鼻炎丸
鼻炎康片
急性鼻炎
慢性鼻炎
疗效观察
Rhinitis pill
Rhinitis kang tablet
Acute rhinitis
Chronic rhinitis
Curative effects
