摘要
糖尿病视网膜病变(DR)是最常见的糖尿病微血管并发症,早期即出现视网膜缺血缺氧,进而导致一系列细胞因子紊乱,局部内环境失衡。而低氧诱导因子(HIF-1)与细胞内的缺氧反应密切相关,在DR早期多条信号通道通过调控HIF-1活性提高血管内皮细胞生长因子(VEGF)的表达,其与DR新生血管的形成有直接关系。理论上,干预信号通道中任何一种激酶都有可能阻止DR的发展。因此,参与信号通道的各级分子都有可能成为治疗DR的潜在靶目标。
Diabetic retinopathy（DR）is the most common microvascular complication of diabetes mellitus.Ischemia and hypoxia in early diabetic retinopathy result in a series of cytokines disorders and local inner environment imbalances.Hypoxia-inducible factor-1（HIF-1）is closely related to intracellular anoxia,many signal pathways may modulate the activation of HIF-1 which can promote the vascular endothelial growth factor expression of early DR.It directly related to neovascularization of DR.In theory,any intervention of the kinase in signal pathways may prevent the development of DR.Therefore,molecular which participate in the signal pathways could be the potential target for DR treatment.
出处
《医学综述》
2011年第21期3207-3210,共4页
Medical Recapitulate
基金
中国上海市科学技术委员会自然科学基金(10ZR1418500)
