摘要
目的研究在不同环境温度对大鼠的血液流变学指标的影响。方法将7组大鼠(每组10只)分别在温度为7、12、16、22、28、32、35℃环境下饲养7 d后,用心脏穿刺法采集大鼠血液5 mL,肝素抗凝,血液采集完毕后2 h内检测血液流变学各项指标。结果环境温度在7、12、32、35℃时,血液流变学指标异常,红细胞可变性降低,毛细血管阻力增高,红细胞易聚集,从而引起机体血液循环障碍,使局部血流缓慢,造成缺血缺氧,影响组织的代谢和功能。结论血液流变性指标值在16～28℃的温度范围内最佳,血流的阻力小,红细胞的流变性好。机体保持良好微循环的最低环境温度7℃,最高环境温度32℃。
Objective To study different ambient temperatures effected on hemorheological characteristics of rats.Methods 70 rats were divided into 7 groups evenly and raised at the ambient temperature of 7,12,16,22,28,32 and 35 ℃,respectively,for 7 days.5 mL blood was collected by heart puncture technique from each rat to test their hemorheological parameters within 2 hours.Results When the ambient temperature was at 7,12,32 or 35 ℃,the hemorheological parameters were abnormal,the variability of erythrocytes was reduced,the resistance of capillaries was increased and the erythrocytes was assembled easily,thus preventing the normal blood circulation,slowing the local blood stream,causing the hypoxia and affecting the organic metabolism and function.Conclusions The hemorheological parameters were optimal within the ambient temperature range of 16~28 ℃,with the resistance of blood flow being smaller and the rheological properties of red blood cells being better.As for keeping the good microcirculation of the organism,it seems that the lowest and highest ambient temperature should be around 7 ℃ and 32 ℃,respectively.
出处
《医用生物力学》
EI
CAS
CSCD
2011年第5期465-470,共6页
Journal of Medical Biomechanics
基金
国家自然科学基金重点资助项目(50838009)
关键词
血液
流变学
环境温度
大鼠
阻力
Blood
Rheology
Ambient temperature
Rats
Resistance
