摘要
目的探讨125I粒子植入在恶性脑胶质瘤治疗中的作用。方法将46例经组织细胞学确诊的复发恶性胶质瘤病人随机分成2组:125I组21例,手术切除复发肿瘤且术中植入125I粒子;对照组25例,手术切除复发肿瘤加或不加去骨瓣减压。两组术后均采用尼莫司汀辅助化疗。结果125I组肿瘤全切除15例,次全切除3例,部分切除3例;对照组肿瘤全切除17例,次全切除4例,部分切除4例。术后并发症125I组9例,对照组8例,均经保守治疗治愈。随访6～36个月,125I组中位生存时间8.0个月,平均生存时间8.9个月,6个月累积生存率56.0%,12个月累积生存率31.4%;对照组中位生存时间4.0个月,平均生存时间5.4个月,6个月累积生存率16.8%,12个月累积生存率2.9%;两组生存时间和生存率差异均有统计学意义(P<0.05)。结论125I粒子植入治疗恶性脑胶质瘤疗效确切,且无明显副作用,是一种安全、有效的治疗方法。
Objective To explore the role of ^25Ⅰ seed implantation in the treatment of malignant gliomas. Methods Forty-six patients with malignant glioma recurrence confirmed by histocytology were randomly divided into ^25Ⅰ group （n=21） and control groups （n=25）. Tumor resection and ^25Ⅰseed implantation were performed in nsI group, and tumor resection with or without decompressive craniectomy was done in control group. Adjuvant chemotherapy with Nimustine was given after surgery. Results Total tumor resection was achieved in 15 patients, subtotal resection in 3 and partial resection in 3 in ^25Ⅰ group. While total tumor resection was achieved in 17 patients, Subtotal resection in 4 and partial resection in 4 in control group. Postoperative complications occurred in 9 patients of ^25Ⅰ group and in 8 of control group, and all the patients were cured by conservative treatment. During a follow-up period of 6 to 36 months, the median survival time in ^25Ⅰ group was 8.0 months, the average survival time 8.9 months, cumulative survival rate of 6 months 56.0% and cumulative survival rate of 12 months 31.4%. While the median survival time in control group was 4.0 months, the average survival time 5.4 months, cumulative survival rate of 6 months 16.8% and cumulative survival rate of 12 months 2.9%. There was statistical significance in survival time and survival rate between two groups （P〈0.05）. Conclusions ^25Ⅰ seed implantation is effective without obvious toxicity, and can be safely and effectively used for the treatment of malignant gliomas.
出处
《中国微侵袭神经外科杂志》
CAS
北大核心
2011年第11期484-486,共3页
Chinese Journal of Minimally Invasive Neurosurgery
