摘要
目的探讨难以分类的原发性头痛患者的临床特点及可能的发病机制。方法南方医科大学南方医院神经内科自2008年8月至2011年3月收治难以分类原发性头痛患者112例，在发作期行经颅多普勒超声（TCD）、脑电图（EEG）以及汉密顿焦虑量表（HAMA）检查，分析TCD显示的血流速度异常、EEG异常与HAMA评分的关系。结果TCD检测显示脑血流速度异常81例（72.3％）；EEG检查发现脑电活动异常31例（27．7％），其中轻度异常25例（22.3％），中度异常6例（5.3％）；HAMA量表检测显示〈7分43例（38．4％），7-14分33例（29．5％），〉14分36例（32．1％）。无论在TCD显示血流速度异常还是正常情况下，EEG正常与异常患者HAMA评分比较差异均无统计学意义（P〉0．05）。无论在EEG异常还是正常情况下，TCD显示正常与异常患者HAMA评分的比较差异无统计学意义（P〉0．05）。结论难以分类原发性头痛与精神和心理疾病共存的情况不可忽视，且颅内血流动力学也有一定程度的变化。对于此类患者，给予改善情绪和调节血流动力学的药物可能有益。
Objective To investigate the clinical characteristics and mechanism of unclassified primary headache. Methods One hundred and twelve patients suffered from unclassified primary headache, admitted to our hospital from August 2008 to March 2011, were enrolled. Transcranial Doppler （TCD） ultrasonography, EEG and Hamilton Depression Rating Scale （HDRS） were performed on patients during headache attack. The correlations between both abnormalities of blood flow velocity in TCD and EEG and scores of HDRS were analyzed. Results TCD showed abnormality of cerebral blood flow velocity in 81 patients （77.3%）. EEG showed mild abnormality of electrical activity in 25 patients （22.3%） and medium abnormality in 6 patients （5.3%）. The scores of HDRS in 43 patients （38.4%） were below 7 points, while those in 33 patients （29.5%） were between 7 and 14 points, and those in 36 patients （32.1%） were over 14 points. The scores of HDRS between patients with normal EEG and abnormal EEG showed no significant differences under circumstance that normal/abnormal cerebral blood flow velocity was noted under TCD （P〉0.05）; the scores of HDRS between patients with normal TCD and abnormal TCD showed no significant differences under circumstance that normal/abnormal electrical activity was noted under EEG （P〉0.05）. Conclusion The patients with unclassified primary headache might have such psychiatric problem as anxiety and cerebral hemodynamic changes. Relevant medicine for these malfunctions could be considered in these patients.
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2011年第11期1164-1167,共4页
Chinese Journal of Neuromedicine
关键词
原发性头痛
经颅多普勒超声
脑电图
焦虑
Primary headache
Transcranial Doppler ultrasonography
EEG
Depression
