摘要
目的:总结癌性恶病质发病机制及实验研究现状,探讨厌食、机体代谢异常、细胞因子在恶病质发生中的作用机制,整理恶病质基础实验研究进展。方法:应用PubMed及CNKI期刊全文数据库检索系统,以"恶病质"、"发病机制"和"实验研究"等为主题词,检索2005-2011年的相关文献,共检索到61篇文献。纳入标准:1)恶病质的发病机制研究;2)厌食、机体代谢异常、细胞因子在恶病质发生中的作用;3)有关恶病质的基础实验研究。根据纳入标准符合分析的文献有29篇。结果:恶病质是晚期癌症患者死亡的重要原因。厌食、机体代谢异常、细胞因子变化促使了恶病质的发生,许多学者通过基础实验研究了恶病质动物模型及药物干预作用,并取得了良好效果。结论:恶病质发病机制较为复杂,有待进一步深入系统研究。药物干预尤其是中医中药的治疗,是防治恶病质的一个重要措施。
OBJECTIVE： To summarize the mechanism and experimental study of cachexia, and discuss the mechanism and classify advanced of experimental study of the cachexia. METHODS： A total of 61 articles on tubular carcinoma of breast published between 2005-2011 were retrived in Pubmed and CNKI with the key of words of ＂cachexia, mechanism,experimental study＂. Inclusion criteria： 1） The mechanism of cachexia ; 2）The function of Anorexia, body metabolic abnormalities and cell factor in cachexia;3）Basic experimental study related to cachexia. Twenty-nine papers were collected. RESULTS： Cachexia is the important reason for the die of terminal cancer patients. Anorexia, body metabolic abnormalities and cell factor are the primary mechanism. And many researchers studied the model of animals and the interference therapy and achieved good results. CONCLUSION： The mechanism of cachexia becomes more systematic, and drug interference especially the interference of Traditional Chinese Medicine which is an important measure on treating cachexia.
出处
《中华肿瘤防治杂志》
CAS
2011年第18期1494-1496,共3页
Chinese Journal of Cancer Prevention and Treatment
基金
国家自然基金项目(81072832)
中国科学院细胞与生化研究所国家重点实验室开放课题(LMCBKF2009001)
教育厅课题(J10LF06)
关键词
恶病质
发病机制
实验探讨
综述文献
cachexia
nosogenesis
experiment discuss
review literature
