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自然杀伤细胞在移植免疫中的双重作用 被引量：3

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摘要 自然杀伤（natural killer,NK）细胞是天然免疫系统的主要效应细胞,是机体三大类淋巴样细胞之一, 位于机体防御体系的第一道防线,具有广泛的生物学功能.NK细胞不需要预先刺激即可识别各种肿瘤细胞和病毒感染的细胞.
作者 石炳毅
机构地区 中国人民解放军第
出处 《器官移植》 CAS 2011年第6期301-303,共3页 Organ Transplantation
基金 国家科技支撑计划项目(2008BAI60B00)
关键词 自然杀伤细胞 移植免疫 天然免疫系统 淋巴样细胞 生物学功能 效应细胞 防御体系 病毒感染
分类号 R392.12 [医药卫生—免疫学]
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参考文献19

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  • 3Kroemer A, Xiao X, Degauque N, et al. The innate NK cells, allograft rejection, and a key role for IL-15[J]. J Immunol, 2008, 180 (12): 7818-7826.
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  • 5Uehara S, Chase CM, Kitchens WH, et al. NK cells can trigger allograft vasculopathy: the role of hybrid re- sistance in solid organ allografts[ J]. J Immunol, 2005, 175 (5): 3424-3430.
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同被引文献37

  • 1Lai L,Kolber-Simonds D,Park KW. Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning[J].Science,2002,(5557):1089-1092.
  • 2Pan GZ,Yang Y,Zhang J. Bone marrow mesenchymal stem cells ameliorate hepatic ischemia/reperfusion injuries via inactivation of the MEK/ERK signaling pathway in rats[J].Journal of Surgical Research,2012,(02):935-948.
  • 3Guo Y,Chen W,Wang W. Simultaneous diagnosis and gene therapy of immuno-rejection in rat allogeneic heart transplantation model using a T-cell-targeted thera-nostic nanosystem[J].ACS Nano,2012,(12):10646-10657.
  • 4Bishop GA, Ierino FL, Sharland AF, et al. Approaching the promise of operational tolerance in clinical transplantation[J]. Transplantation, 2011, 91 (10): 1065-1074.
  • 5Girmanova E, Hruba P, Viklicky O. Circulating biomarkers of tolerance [ J]. Transplant Rev, 2015, 29 (2) : 68-72.
  • 6Sagoo P, Perucha E, Sawitzki B, et al. Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans [ J ]. J Clin Invest, 2010, 120 (6): 1848-1861.
  • 7Newel1 KA, Asare A, Kirk AD, et al. Identification of a B cell signature associated with renal transplant tolerance in humans[J]. J Clin Invest, 2010, 120 (6): 1836- 1847.
  • 8Starzl TE, Murase N, Demetris AJ, et al. Lessons of organ-induced tolerance learned from historical clinical experience [ J ]. Transplantation, 2004, 77 (6) : 926- 929.
  • 9VanBuskirk AM, Burlingham WJ, Jankowska-Gan E, et al. Human allograft acceptance is associated with immune regulation[J]. J Clin Invest, 2000, 106(1) : 145-155.
  • 10Moraes-Vieira PM, Silva HM, Takenaka MC, et al. Differential monocyte STAT6 activation and CD4 ( + ) CD25 ( + ) Foxp3 ( + ) T cells in kidney operational tolerance transplanted individuals [ J ]. Hum Immunol, 2010, 71 (5): 442-450.

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器官移植
2011年 第6期

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