期刊文献+

鼠神经生长因子治疗糖尿病神经病变65例观察 被引量:4

下载PDF
导出
摘要 目的探讨鼠神经生长因子治疗糖尿病神经病变的疗效。方法选取2006年1月至2010年12月于本院进行治疗的130例糖尿病神经病变患者为研究对象,将其随机分为对照组(常规治疗组)65例和观察组(鼠神经生长因子组)65例,后将两组患者的治疗总有效率、不良反应发生率及治疗前后运动、感觉神经传导速度进行统计及比较。结果观察组的治疗总有效高于对照组,运动、感觉神经传导速度优于对照组,(P<0.05),差异有统计学意义,而两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论鼠神经生长因子治疗糖尿病神经病变的疗效好,安全性高,总体优势明显。
作者 赵继伟
机构地区 铁岭市中心医院
出处 《中国现代药物应用》 2011年第20期22-23,共2页 Chinese Journal of Modern Drug Application
  • 相关文献

参考文献4

二级参考文献33

  • 1李剑波 陈家伟.糖尿病神经病变的发病机理及其现代认识[J].实用糖尿病杂志,1997,(5):3-3.
  • 2[1]Resnick HE,Stansberry KB,Harris TB,et al. Diabetes ,peripheral neuropathy,and old age disability[J]. Muscle Nerve, 2002, 25(1) :43-50.
  • 3[2]Yagihashi S,Yamagisbi SI,Wada RR ,et al. Neuropathy in diabet ic mice overexpressing human aldose reductase and effects of aldose reductase inhibitor[J]. Brain,2001,124(12):2448-2458.
  • 4[3]Obrosova IG,Fathallah L,Stevens MJ. T aurine counteracts oxidative stress and nerve growth factor deficit in early experimental diabetic neuropathy[J]. Exp Neurol,2001,172(1) :211-219.
  • 5[4]Xu G,Sima AAF. Altered immediate early gene expression in injured diabetic nerve: implications in regeneration [J]. J Neu ropathol Exp Neurol, 2001,60: 972-983.
  • 6[5]Hall KE, Liu J, Sima AA, et al. Impaired inhibitory G-protein function contributes to increased calcium currents in rats with diabetic neuropathy[J]. J Neurophysiol, 2001, 86 (2): 760-770.
  • 7[6]Shah BS,Gonzalez I,BramwelI S,et al. β3,a nocel auxiliary subunit for the voltage gated sodium channel is upregulated in senso ry neurons following streptozotocin induced diabetic neuropathy in rat[J]. Neurosci Lett,2001,309:1-4.
  • 8[7]Kamiya H, Nakamura J, Hamada Y, et al. Polyol pathway and protein kinase C activity of rat schwannoma cells[J]. Diabetes Metab Res Rev,2003,19(2):131- 139.
  • 9[8]Eaton JW,Qian M. Interactions of copper with glycated proteins:possible involvement in the etiology of diabetic neuropathy[J].Mol Cell Biochem, 2002,235:135-142.
  • 10[9]Meijer JW,Bosma E,Lefrandt JD,et al. C inical diagnosis of dia betic polyneuropathy with the diabetic neuropatby symptom and diabetic neuropathy examination scores[J]. Diabetes Care, 2003,26(3):697-701.

共引文献295

同被引文献38

  • 1尚正良,许虹.2型糖尿病合并脑梗死发病机制及血液检验研究进展[J].医学信息(医学与计算机应用),2014,0(36):461-462. 被引量:1
  • 2各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量:33029
  • 3唐霓,唐显玲.糖尿病血液流变性改变与微血管病变关系的研究进展[J].微循环学杂志,2007,17(3):60-61. 被引量:23
  • 4Callaghan BC, Cheng HT, Stables CL,et al. Diabetic neuropa- thy: clinical manifestations and current treatments [J].The Lancet Neurology,2012, 11(6) : 521-534.
  • 5Okawa T,Kamiya H, Himeno T, et al. Transplantation of neu- ral crest-like cells derived from induced pluripotent stem ceils improves diabetic polyneuropathy in mice[J]. Ceil transpianta tion, 2013,22(10): 1 767-1 783.
  • 6SANDER O,SANDER K,POPPERT H. Stroke in type 2 diabetes [J]. Br J Diabetes Vascular Dis,200S,S (5): 222- 229.
  • 7刘新民.实用内分泌[M].第2版.北京:人民军医出版社,1998:315-319.
  • 8全国第四届脑血管病学术会议.各类脑血管病诊断标准:脑卒中患者神经功能缺损程度评分标准[J].中华神经科杂志,1995,29(6):378-383.
  • 9ULUDUZ D, INCE B, BOZHUOLCAY M.Stroke paterns etiology and prognosis in patients with diabetes mellitus [ J ]. Neurology, 2005,64(3 ):581 -583.
  • 10FYODOROVA M Z,KLOCHKOVA C N,ANKUDINOV I V.Microrheology disorders and their biochemical correlates in patients with diabetes mellitus and initial manifestations of hypertension [J]. Bull Exp Biol Med,2008,145(2): 188-189.

引证文献4

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部