摘要
目的探讨血清胱抑素C(Cys-C)在高血压肾病患者外周血中检测的临床意义。方法 102例高血压患者根据尿微量白蛋白排泄率(UAER)分为三组即Ⅰ﹑Ⅱ﹑Ⅲ组。清晨空腹抽取静脉血3ml检测血Cys-C、2-MG、BUN、Cr的浓度。结果高血压肾病患者Ⅰ组Cys-C浓度(0.92±0.14)mg/L,高于对照组(0.79±0.26)mg/l,差异具有统计学意义(P>0.05),其它三项指标结果高于对照组,但与对照组相比差异不具有统计学意义。Ⅱ组和Ⅲ组患者四项指标均高于对照组,且差异具有统计学意义(P<0.01)。结论 Cys-C敏感性和特异性高于2-MG、BUN、Cr,是反映肾小球滤过率变化的理想的内源性标志物。
Objective To explore the clinical significance of serum Cys - C measured in the pa- tients with hypertensive nephropathy. Methods Totally 104 patients were divided into three groups which were I group（30）, Ⅱ group（35） andⅢ group（37） according to the UAER level,fasting serum Cys -C ,2 -MG, BUN, Cr levels were measured as well as the normal control group（30）. Results The Cys - c level of I group was （0. 92 ± 0. 14） mg/1 which was higher than the level of the normal control group which was （0. 79 ±0. 26 ） mg/1, the difference had statistic significance （ P 〈 0. 05 ）, the levels of the other three indexes were higher than normal control group, but the difference had no statis- tic significance （P 〉 0.05 ）. With the aggravation of the disease, Cys -C ,2 -MG, BUN and Cr levels increased in Ⅱand Ⅲ groups, which were significantly higher than those in normal control group （ P 〈 0. 01 ）. Conclusions Cys - C is an ideal endogenous marker in the reflection of changes of glomerular filtration rate, whose sensitivity and specificity were higher than those of 2 - MG, BUN and Cr.
出处
《医药论坛杂志》
2011年第19期44-45,共2页
Journal of Medical Forum
关键词
高血压肾病
血清胱抑素C
外周血
Hypertensive nephropathy
Serum cystatin C
Peripheral blood
