摘要
目的研究多发性骨髓瘤(Multiple myeloma,MM)患者的遗传学特点与临床意义。方法回顾性分析127例MM患者的遗传学结果。结果 127例MM患者中异常染色体检出率为20.3%(35/127),结构畸变多累及1、13、14、17号染色体,复杂畸变的染色体多见,占51.4%(18/35)。核型异常的MM患者对常规化疗疗效差,预后较差,伴有13q14缺失的患者死亡率较不伴有的患者高(P<0.05)。结论 13q14缺失及IgH易位等是MM常见的核型异常,13q14缺失等是预后不良因子。
Objective To investigate the genetics characteristics and clinically significance to multiple myeloma.Methods Retrospective analysis of genetic results of MM patients.Results In 127 patients,35 cases（20.3%）were chromosome aberrations.Structural aberrations mainly involved chromosome 1,13,14 and 17.Complex aberrations were detected in 18 cases（51.4%）.The patients with chromosome aberrations demonstrated poor responses to chemotherapy and had poor prognosis,while the patients with del（13q14）had higher fatality than without such aberration（P0.05）.Conclusion There are high frequency of 13q14 deletion and IgH translocation in MM.13q14 deletion are poor prognosis factors for MM patients.
出处
《中国热带医学》
CAS
2011年第10期1279-1280,共2页
China Tropical Medicine
