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Tim-1基因多态性与疾病的关系

Relationship of Tim-1 gene polymorphisms and disease
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摘要 T细胞免疫球蛋白黏蛋白分子（Tim）-1是Tim基因家族的重要成员，主要在T细胞表面表达，在调节T细胞免疫应答中起着重要作用。近年发现Tim-1基因多态性可能与过敏性疾病、自身免疫性疾病及感染等多种疾病有关。阐明Tim-1基因多态性与相关疾病的关系，可能会对这些疾病发病机制的明确产生深远的影响，对疾病的预防及治疗提供新的手段和方法。 As an importantmember of Tim gene family, T cell immunoglobulin domain and mucin domain protein （Tim） - 1 mainly expressed in T cell surface and adjust T cells immune response. Recent studies have found that Tim-1 gene polymorphisms may be linked with allergic diseases, autoimmune diseases and infection diseases. The review of relationship between Tim-1 polymorphism and diseases will have profound and long-term impact to expound the pathogenesis, providing new method to prevent and treat diseases.
作者 黄志英（综述） 程宝金（审校）
机构地区 南京医科大学附属常州第二人民医院儿科
出处 《国际儿科学杂志》 2011年第6期602-605,共4页 International Journal of Pediatrics
关键词 T细胞免疫球蛋白黏蛋白分子-1 基因多态性 过敏性疾病 自身免疫性疾病 T cell immunoglobulin domain and mucin domain protein Gene polymorphism Allergic diseases Autoimmune diseases
分类号 R593.1 [医药卫生—内科学]
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参考文献31

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  • 2Kuchroo VK, Umetsu DT, DeKruyff RH, et al. The TIM gene family: emerging roles in immunity and disease. Nat Rev ]mmunol, 2003,3 (6) :454-462.
  • 3Umetsu SE, Lee WL, Mclntire JJ, et al. TIM-I induces T cell at-'.livation and inhibits the development of peripheral tolerance. Nat Immunol, 2005,6(5 ) :447-454.
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二级参考文献61

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国际儿科学杂志
2011年 第6期

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