摘要
目的探讨纳洛酮治疗首发急性右心力衰竭的临床疗效。方法将2001年1月至2007年5月首发急性右心力衰竭52例随机分为纳洛酮组(32例)和对照组(20例)。对照组按常规综合性治疗,纳洛酮组在对照组常规综合性治疗的基础上给予纳洛酮首剂0.8mg静脉注射,必要时2～4h后重复0.8mg静脉注射,继以1.2mg置于500mL液体内静脉滴注。比较治疗24h后心率、收缩压、每搏量以及心功能变化。结果纳洛酮组总有效率84.4%,病死率6.6%;对照组总有效率60%,病死率18.3%。纳洛酮组心率、收缩压、每搏量以及心功能明显改善(P<0.01),与对照组比较,疗效优于对照组(P<0.05)。结论在常规综合治疗心力衰竭的基础上,应用纳洛酮治疗首发急性右心力衰竭是有效的药物。
Objective To investigate the nalaxone treating first acute right heart failure.Methods52 patients with FARHF were divided into the naloxone group(30cases)and control group(20cases)at random.Patients in control group were given general comprehensively treating.Patients in naloxone group were given naloxone as well as comprehensively treating,were given intravenously 0.8 mg of first dose,if it was necessary,repeated 0.8 mg of dose,and continuously dropped for 1.2 mg was added into liquid 500 mL.After treatment of 24 hours,were compared the changes of HR、SBP、SV and heart function.ResultsIn the naloxone group,the total effective rates were 84.4%,the mortality rates were 6.6%;in control group.The total effective rates were 60%,the mortality rates were 18.3%.The difference of the effective rate of the naloxone group be treatment was statistically significant(P<0.01);to The difference of the effective rate of between group naloxone and control(P<0.05).ConclusionIn general comprehensively treating add to naloxone,shows favorable effect on first acute right heart failure.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2008年第S1期113-114,共2页
Chinese Journal of Practical Internal Medicine
