摘要
目的探讨根除幽门螺杆菌（helicobacter pylori，Hp）对飞行员胃增生性息肉的影响并初探其机制。方法收集Hp阳性的胃增生性息肉飞行员病例46例，按照是否采用了根除Hp治疗分为根除Hp治疗组（根治组，三联疗法：奥美拉唑、阿莫西林、甲硝唑或左氧氟沙星）和奥美拉唑对照组，于治疗后6、12、24个月进行胃镜和组织学检查，以观察息肉变化和黏膜炎症情况。结果治疗后根治组胃黏膜炎症评分明显降低，与对照组比较差异有统计学意义（z=-3．441，P〈O．01）。根治组随着Hp根除和胃黏膜炎症积分减少，息肉于24个月内消失率达95．8％，对照组24个月内息肉消失率为9．0％，差异有统计学意义（x^2=31．401，P〈O．01）。结论Hp与飞行员胃增生性息肉有一定关系，其机制与胃粘膜炎症密切相关；根除Hp有利于治疗胃增生性息肉和预防其发生。
Objective To study the therapeutic effects of eradicating helicobacter pylori （Hp）on the gastric hyperplasic polyps in military pilots. Methods Forty-six Hp infected patients with gastric hyperplasia polyps were averagely divided into eradication therapy group （treated by omeprazole, amoxicillin and levofloxacin or tinidazole） and control group （treated by omeprazole only）. All patients were examined by gastroscopy before and 6, 12, and 24 months after the treatments, meanwhile histopathological examination and Hp determination were done. Results By 24-month eradication therapy, the mucosal inflammation degree was significantly lower than that in control group （Z= -3. 441, P〈0.01） and the elimination rate of gastric hyperplastic polyps reached 95.8% comparing to 9.0% in control group （X^2=31. 401, P〈0. 01）. Conclusions The gastric hyperplastic polyps are closely related with Hp infection and the mechanisms may be related to gastric mucosal inflammation. The eradication of Hp would be helpful to the prevention and treatment of the gastric hyperplastic polyps for pilots.
出处
《中华航空航天医学杂志》
CSCD
2011年第3期207-209,F0004,共4页
Chinese Journal of Aerospace Medicine
关键词
螺杆菌
幽门
胃黏膜
息肉
药物疗法
Helicobacter pyloril Gastric mucosa
Polyps
Drug therapy
