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Relationship between DNA ploidy, expression of ki-67 antigen and gastric cancer metastasis 被引量:9

Relationship between DNA ploidy, expression of ki 67 antigen and gastric cancer metastasis *
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摘要 AIM To evaluate the relationship between the expression of Ki 67 antigen and the pathobiological behaviours of gastric cancers especially their distant metastases. METHODS Fifty six specimens of gastric cancer routinely fixed in formalin and embedded in paraffin (FFEP) were studied by immunohistochemical method. RESULTS Expression of Ki 67 antigen was significantly related to the distant metastases to liver, ovary and adrenal gland ( P <0 005), but not related to the histological type, growth pattern, depth of invasion, histological differentiation and the metastases to local lymph nodes ( P >0 05). Furthermore, the Ki 67 antigen expression was significantly related to the DNA aneuploidy pattern, which is closely related to poor prognosis ( P <0 05). CONCLUSION Overexpression of Ki 67 can be used as an objective marker of the proliferative activity for predicting prognosis of gastric cancer and metastatic potential to distant organs.
出处 《World Journal of Gastroenterology》 SCIE CAS CSCD 1999年第1期15-16,共2页 世界胃肠病学杂志(英文版)
关键词 Ki 67 ANTIGEN NEOPLASMS METASTASIS IMMUNOCHEMISTRY DNA PLOIDY stomach neoplasms/pathology Ki 67 antigen neoplasms metastasis immunochemistry DNA ploidy stomach neoplasms/pathology
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