摘要
蛋白质精氨酸甲基化是重要的细胞翻译后修饰方式,参与众多生命过程.精氨酸的甲基化修饰与糖代谢相关疾病如糖尿病、糖耐量异常密切相关.蛋白质精氨酸甲基化转移酶(proteinarginine methyltransferases,PRMTs)活性下降及表达异常是糖代谢疾病的重要发病基础.目前研究表明,PRMT1、PRMT4、PRMT5在糖代谢调节中均扮演重要角色,与糖代谢关键酶如磷酸烯醇式丙酮酸羧基激酶、葡萄糖6磷酸酶,胰岛素受体-胰岛素受体配体1-磷脂酰肌醇3激酶通道及其它通路密切相关.给予甲基化抑制剂MTA及siRNA干扰甲基化则可引发糖代谢紊乱,进而诱发糖代谢疾病.糖尿病药物罗格列酮、氨基胍与蛋白质精氨酸甲基化也有一定联系.深入研究蛋白质精氨酸甲基化与糖代谢调节之间的联系及机制,可为防治糖代谢疾病及相关并发症提供更多的理论依据.
Protein arginine methylation is one of the most important post-translational modifications and participate in a number of cellular processes that linked to carbohydrate metabolism-associated diseases like diabetes and impaired glucose tolerance.Abnormal expression of arginine methyltransferases（PRMTs） and decreased enzyme activity related to the mechanism underlying its associated diseases.Current studies have shown that PRMT1,PRMT4,PRMT5 played crucial roles in glucose metabolism regulation,and correlated with key enzymes such as phosphoenolpyruvate carboxykinase,glucose-6-phosphatase,and signal pathways like insulin receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase.Methylation inhibitor MTA or small interfering RNA of PRMTs induced metabolic disturbance and caused disease symptoms.Antidiabetic agents,rosiglitazone and aminoguanidine affected arginine methylation.Further investigation on the roles of PRMTs in metabolic diseases may contribute to the understanding and development of preventions and treatments.
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2011年第11期993-997,共5页
Chinese Journal of Biochemistry and Molecular Biology
