摘要
目的系统评价益气养阴活血法联合贝那普利治疗早期2型糖尿病肾病的疗效。方法全面收集并纳入符合标准的文献,按Cochrane协作网肾脏病组的质量评价标准评价纳入研究的方法学质量,提取有效数据并采用Revman5.0软件进行分析。结果共纳入9个临床随机对照实验文献,包括686例早期2型糖尿病肾病患者,但方法学质量评价显示纳入研究质量不高,仅有1个B级,其余8个均为C级。Meta分析显示,与单用贝那普利相比,益气养阴活血法联用贝那普利在改善早期2型糖尿病肾病患者某些指标方面具有优势,仅有1个文献报道试验组有2例干咳,未见其他不良反应。结论与单用贝那普利相比,益气养阴活血法联合贝那普利有更好的疗效且相对安全,但对这些结果的解释应持谨慎态度,期待更多高质量的随机双盲对照试验提供高质量的证据。
Objective To evaluate the effectiveness of benazepril combinating with supplementing Qi, nourishing Yin and vivifying blood flow on type-2 Incipient Diabetic Nephropathy. Methods Literatures concerning type-2 Incipient Diabetic Nephropathy were collected and assessed according to the Cochrane Handbook for Systematic Reviews of Interventions. Revman 5.0 was used for meta analysis. Results Nine RCTs of 686 patients of incipient diabetic nephropathy were analyzed. One trial was classified as grade B,others were classified as grade C.Compared with benazepril alone,combinating the Traditional Chinese Medicine（TCM）of supplementing Qi,nourishing Yin and vivifying blood flow could significantly decreased some indexes of type-2 Incipient Diabetic Nephropathy. Only one trial reported that two patients suffered from dry cough. Conclusion Combinating the TCM of supplementing Qi, nourishing Yin and vivifying blood flow showed some effect and the method was found relatively safe in treating patients with type-2 Incipient Diabetic Nephropathy. However, the evidence is insufficient to determine the effectiveness. Further large-scale trials are required to define the role of supplementing Qi,nourishing Yin and vivifying blood flow in the treatment of type-2 Incipient Diabetic Nephropathy.
出处
《热带医学杂志》
CAS
2011年第10期1147-1150,共4页
Journal of Tropical Medicine
基金
广东省"211工程"三期重点学科建设项目
关键词
早期2型糖尿病肾病
益气养阴活血法
随机对照试验
系统评价
type-2 of incipient diabetic nephropathy
supplementing Qi
nourishing Yin and vivifying blood flow
randomized controlled trial
systematic review
