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甲基化和去甲基化在肿瘤发生与治疗中的作用 被引量:10

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摘要 传统观点认为,肿瘤发生、发展的主要机制是各种物理、化学、生物致癌因素造成DNA序列变异,从而导致细胞生长、分化失控,最终导致肿瘤的形成。近年来,随着研究的深入,人们发现DNA序列以外的调控机制异常在肿瘤的发生、发展过程中更为普遍,这种不依赖于DNA序列变化的可遗传的调控机制称为表观遗传学机制,该机制是与DNA突变无关的可遗传的表型变化。
出处 《现代肿瘤医学》 CAS 2011年第11期2352-2355,共4页 Journal of Modern Oncology
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参考文献30

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二级参考文献25

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