摘要
ＤｅｔｅｃｔｉｏｎｏｆＣｉｒｃｕｌａｔｉｎｇＡｕｔｏａｎｔｉｂｏｄｉｅｓｔｏβ２┐ＡｄｒｅｎｅｒｇｉｃＲｅｃｅｐｔｏｒｓｉｎＰａｔｉｅｎｔｓｗｉｔｈＡｓｔｈｍａＷｕＪｉａｎｑｉｎｇ（吴剑卿）ＹｉｎＫａｉｓｈｅｎｇ（殷凯生）＊ＹａｎｇＹｕ（杨玉）＊Ｄｅ...
To investigate the roles of autoantibodies to β 2 adrenergic receptors in the pathogenesis of asthma, the positive chronotropic action of the β 2selective adrenergic agonist, clenbuterol, was investigated on cultured neonatal rat cardiomyocytes, firstly. Then we detected the autoantibodies to β 2adrenergic receptors through the sera of patients with asthma could inhibit the positive chronotropic action of clenbuterol. The results showed that all the sera of the patients with asthma (16 cases) had the autoantibodies to β 2 adrenergic receptors; in contrast, none of the control subjects (20 cases) had the autoantibodies to β 2 adrenergic receptors, and that the inhibitory autoantibodies were IgG type. This study suggests that the autoantibodies to β 2 adrenergic receptors may play an important role in the pathogenesis of asthma.
