摘要
Ebselen was selected as the lead compound and a series of derivatives of benzisoselenazolone was designed and synthesized with pharmacological interest. Under ether water NaHCO 3 reaction system, 2 chloroselenobenzoyl chloride was treated with a series of sulfanilamide and ten Ebselen derivatives with SO 2NHR group attached to the p position of 2 phenyl moiety were prepared in good yields. All these new conpounds were characterized by 1H NMR, IR, UV spectra and elemental analysis.
Ebselen was selected as the lead compound and a series of derivatives of benzisoselenazolone was designed and synthesized with pharmacological interest. Under ether water NaHCO 3 reaction system, 2 chloroselenobenzoyl chloride was treated with a series of sulfanilamide and ten Ebselen derivatives with SO 2NHR group attached to the p position of 2 phenyl moiety were prepared in good yields. All these new conpounds were characterized by 1H NMR, IR, UV spectra and elemental analysis.
