摘要
采用图像分析技术,对5例手术切除肝腺瘤样增生(AHL)的7种细胞核形态参数,即面积(AREA),周长(PERIM),最大直径(DMAX),最小直径(DMIN),等圆度直径(DCIRCLE),圆形指数(FCIRCLE)和形状指数(FSHAPE)进行定量测定,以正常肝细胞(NLC)和肝癌细胞(HCC)作对照。结果:(1)AHL的7种核形态参数均与NLC差异有显著性,三种参数(DMAX,DMIN和FSHAPE)与HCC差异无显著性,提示AHL与NLC在核形态定量特征上不属于同一类细胞群体,前者在一定程度上向HCC靠近;(2)细胞核FCIRCLE和DCIRCLE两参数散点分布图显示,与NLC和HCC的分布形式明显不同,AHL分布离散,范围覆盖NLC和部分HCC区域,提示AHL是一种由处于不同增殖状态的细胞组成的群体;(3)本组5例AHL均发生早期癌变,显示其极高的癌变率。提示AHL符合癌前病变的基本特征,是HCC的重要癌前病变。
Seven cellular parameters in adenomatous hyperplasia of the liver (AHL), compared with normal liver cells (NLC) and hepatocellular carcinoma (HCC), were analyzed quantitatively by measuring the seven parameters of the cell nuclei, the area (AREA), perimeter (PERIM), maximum diameter (DMAX), minimum diameter (DMIN), the equivalent circle diameter (DCIRCLE), circularity shape factor (FCIRCLE) and shape factor (FSHAPE) using computerized image analyzer. The main results were: (1) All the above seven nuclear parameters in AHL were significantly different from those in NLC, three parameters (DMAX, DMIN and FSHAPE) in AHL were not obviously different from those in HCC, indicating that AHL and NLC were not of the same cellular population, and AHL had a tendency of approaching HCC in the nuclear features; (2) Not alike NLC and HCC, the scattered distribution between nuclear FCIRCLE and DCIRCLE in AHL presented a highly dispersed distribution, overlapping the areas of NLC and the greater part of HCC, suggesting that AHL being an abnormal cellular population composed of cells in different proliferative status between NLC and HCC; (3) All of five resected AHL in the present study showed early malignant transformation. We conclude that AHL possesses the general features of precancerous lesion, and should be considered as the important precancerous lesion of HCC.
出处
《中华消化杂志》
CAS
CSCD
北大核心
1996年第S1期65-67,共3页
Chinese Journal of Digestion
关键词
肝腺瘤样增生
癌前病变
图像分析技术
形态定量测定
肝肿瘤
Adenomatous hyperplasia of the liver Image analysis technology Morphometry Percancerous lesion Hepatocellular carcinoma
