摘要
For drugs obeying parallel first-order and Michaelis-Menten elimination kinetics,mathematical analysis concerning the optimum dosage regimen of intravenous infusion is conducted and following equations are derived:where Xo is the intravenous loading dose,Cb the plasma concentration level desired in clinical therapy,V the apparent distribution volume,k0 the rate constant of intravenouns infusion,K the first－order elimination rate constant,Vm the theoretical maximum rate of the Michaelis－Menten elimination process,Km the Michaelis constant.From this dosage regimen,plasma level maintains a constant Cb during the administration period.When K=0 the dosage regimen above is also suitable for drugs obeying Michaelis-Menten elimination kinetics.
For drugs obeying parallel first-order and Michaelis-Menten elimination kinetics,mathematical analysis concerning the optimum dosage regimen of intravenous infusion is conducted and following equations are derived:where X_o is the intravenous loading dose,C_b the plasma concentration level desired in clinical therapy,V the apparent distribution volume,k_0 the rate constant of intravenouns infusion,K the first－order elimination rate constant,V_m the theoretical maximum rate of the Michaelis－Menten elimination process,K_m the Michaelis constant.From this dosage regimen,plasma level maintains a constant C_b during the administration period.When K=0 the dosage regimen above is also suitable for drugs obeying Michaelis-Menten elimination kinetics.
出处
《生物数学学报》
CSCD
北大核心
1996年第4期6-11,共6页
Journal of Biomathematics
