摘要
Human β-globin gene family provides an ideal model for studying the expression and regulation of eukaryotic gene. The five transcriptional active genes arranged 5′ε-~Gγ-~Aγ-δ-β 3′ in the order that they are expressed during development. However, the molecular regulatory mechanism of the human globin gene expression remains to be defined. β-globin gene normally expressed in the adult bone marrow, but not in the embryonic stage, which
