摘要
采用荧光偏振免疫分析法(FPIA),在7名志愿者身上,对氨茶碱单用及与左旋氧氟沙星合用后,血中氨茶碱浓度的变化进行观测.结果表明,合用左旋氯氟沙星后氨茶碱消除速率常数k降低13.6%,清除率CL下降15.6%,半衰期T_1/2延长16.5%(P<0.05),但对峰浓度C_(max)、曲线线下面积AUC,表观分布容积V_d无显著影响(P<O.05).
Aminophylline in blood was determined by FPIA for 7 healthy volunteers having taken aminophylline or aminophylline combined with levofloxacin. The results indicated that levofloxacin made the elimination half life of aminophylline prolong,clearance and elimination rate constant reduced (P<0. 05). There was no significant statistical differences in the apparent distribution volume, the area under the curve and the peak concentration of aminophylline.
出处
《中国临床药学杂志》
CAS
1996年第4期141-143,共3页
Chinese Journal of Clinical Pharmacy
