摘要
报道128例癫痫患者4种抗癫痫药单用与合用的临床疗效以及中毒情况,对128例癫痫患者的血药浓度监测结果进行了分析,着重分析了PHT中毒病例与血药浓度的关系.举例说明TDM工作有助于诊断、处理药物过量中毒;对合并用药的合理性具有指导作用,建议尽量避免多药合用;同时必须密切注意PHT的饱和动力学特征.
128 cases of various types of epilepsy treated with phenytoin(PHT) ,carba-mazepine CBZ),phenobarbital (PB) or sodium valproate (VPA) were reported,serum concentration was measured,in which the toxic cases treated with PHT were chiefly analysed. The result showed as follows: Therapeutic Drug Monitoring (TDM) contributes to diagnosing and dealing with the toxication of excessive drugs. The kinetic characteristic of PHT (Michaelis-Menten kinetics) must be closely noticed. The reciprocal effect among different antiepileptic drugs are complex. Single drug treatment for clinical use was suggested.
出处
《中国临床药学杂志》
CAS
1996年第4期144-147,共4页
Chinese Journal of Clinical Pharmacy
关键词
癫痫
药物监测
血药浓度
苯妥英钠
苯巴比妥
卡马西平
丙戊酸钠
epilepsy
therapeutic drug monitoring
serum concentration
sodium phenytoin
phenobarbital
carbamazepine
sodium valproate
