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Analysis of Plasma Fibrinolysis in the Patients with Acute Cerebral Infarction 被引量:1

Analysis of Plasma Fibrinolysis in the Patients with Acute Cerebral Infarction
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摘要 In the present study, the plasma fibrinolytic activity in 30 cases of cortical artery territory cerebral infarction (CACI) and 32 cases of perforating artery territory cerebral infarction (PACI) within 3 days after ictus, and 30 sexand age-matched controls without cardio-cerebrovascular diseases were evaluated by a comprehensive panel of assay, including the plasma tPA activity, PAI activity, endothelial capacity of tPA release and PAI/tPA ratio. The results showed that the plasma fibrinolysis and the endothelial potential to release tPA responding to stimulation in boch subtypes of the patients were significantly lower than those in the controls, which provide. the theoretical basis for carrying out the thrombolytic therapy in the ischemic stroke. And the study also suggested that increased Plasma PAI activity could increase the risk of AS chrombotic events with increased serum triglyceride level. In the present study, the plasma fibrinolytic activity in 30 cases of cortical artery territory cerebral infarction (CACI) and 32 cases of perforating artery territory cerebral infarction (PACI) within 3 days after ictus, and 30 sexand age-matched controls without cardio-cerebrovascular diseases were evaluated by a comprehensive panel of assay, including the plasma tPA activity, PAI activity, endothelial capacity of tPA release and PAI/tPA ratio. The results showed that the plasma fibrinolysis and the endothelial potential to release tPA responding to stimulation in boch subtypes of the patients were significantly lower than those in the controls, which provide. the theoretical basis for carrying out the thrombolytic therapy in the ischemic stroke. And the study also suggested that increased Plasma PAI activity could increase the risk of AS chrombotic events with increased serum triglyceride level.
出处 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 1995年第2期68-72,共5页 华中科技大学学报(医学英德文版)
关键词 cerebral infarction tissue-plasminogen activator (tPA) plasminogen activator inhibitor (PAI) cerebral infarction, tissue-plasminogen activator (tPA), plasminogen activator inhibitor (PAI)
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