摘要
以体外半固体琼脂培养方法观察了家兔循环血CFU-GM的一般特性及丹参注射液对家兔CFU-GM的动员作用。研究结果显示,家兔循环血CFU-GM正常值为9.10±7.45(范围0～27.33)CFU-GM/1×10~6MNC,其数量无明显性别差异,亦无明显日间周期性变化;丹参注射液可升高循环血CFU-GM数量;当给药剂量1g/kg,连续给药8d后,循环血CFU-GM数量达高峰,为对照组的6.18倍。作者分析,丹参注射液对家兔CFU-GM动员作用的机理可能包括改善骨髓造血微循环、促进造血细胞增殖分化并向外周血迁移等,确切机理尚待进一步研究。丹参具有毒性小、安全范围大、来源方便等优点,以其作为造血祖细胞动员剂,有进一步研究的价值。
Mobilization of CFU-GM into the peripheral blood of rabbit by Injectio radix salvia miltiorrhiza was studied through semisolid agar culture. The number of CFU-GM in rabbit blood was 9.10±7.45 (range 0-27.33) / 1×106, it has no significant sex and time variation, radix salvia miltiorrhiza was administered in 8 consecutive days at a dose of Ig / kg (iv) per day, and a 6.18-fold increase of the peripheral blood CFU-GM was observed. The mechanisms responsible for inducing increase in the peripheral blood CFU-GM number by radix salvia miltiorrhiza need further investigate, and the possibilities might include improving bone marrow microcirculation, promoting proliferation and differentiation of hematopoietic stem cells, and releasing marrow progenitor cells.
出处
《中国实验血液学杂志》
CAS
CSCD
1995年第1期68-73,共6页
Journal of Experimental Hematology
关键词
丹参
粒-巨噬系祖细胞
造血祖细胞动员剂
radix salvia miltiorrhiza CFU-GM hematopoietic progenitor mobilizer
