摘要
１９７９年１月至１９９０年１２月我院治疗１０４例Ⅰ、Ⅱ期鼻腔非何杰金淋巴瘤，根据ＡｎｎＡｒｂｏｒ分期，Ⅰ期７９例，Ⅱ期２５例。所有病人均经病理证实为弥漫性非何杰金淋巴瘤。单纯放疗５１例，放疗和化疗综合治疗５３例。全组５年生存率为６５．７％，Ⅰ、Ⅱ期５年生存率分别为７６．２％和２３．２％，两者有非常显著差别（Ｐ＜０．００１）。病变局限于鼻腔（Ⅰ期局限组）和超出鼻腔侵犯邻近器官（Ⅰ期超腔组）的病人５年生存率分别为９２．３％和５７．３％，有显著差别。临床分期是影响预后最重要的因素，各病理类型之间生存率无显著差别。Ⅰ期局限组单纯放疗即可治愈，不必做颈部预防照射。Ⅱ期和Ⅰ期超腔组建议综合治疗，并选用强烈有效的化疗方案。
AbstractFrom January 1979 to December 1990,104 Patients with stage Ⅰ and Ⅱ lymphoma of thenasal cavity were retrospectively analyzed. All patients had non-Hodgkin’s lymphoma of thediffuse type. According to Ann Arbor Staging System, there were 79 stage Ⅰ,and 25 stage Ⅱ.Fifty-one patients were treated with radiotherapy alone , 53 with combination of radiotherapyand chemotherpy. The overall 5-year survival was 65.7%,with 76.2%for stage Ⅰ and 23.2 % forstage Ⅱ. Patients for stage Ⅱ had poorer prognosis as compared with those for stage Ⅰ.Although no significant differences in survivals were seen between radiotherapy and themultimodality, aggressive chinotherapy seemed to improve results for stage Ⅱ patients,Extent of the extranodal disease also iofluenced results of stage Ⅰpatients. The 5-yearsurvival for patients with stage Ⅰdisease confined to the nasal cavity was 92.3% as comparedwith 57.3%for patients with stage Ⅰdisease extented beyond the nasal cavity. The differencewas of highly statistical significance. We therefore recommend radiotherapy alone forpatients with disease limited to the nasal cavity and intensive chemotherapy combined withradiotherapy for those with disease involved adjacent organs or the regional nodes. Prophylactic neck irradiation should not be given to stage Ⅰpatients as of few of the cervicalnode developed recurrence. Most patients with failures had distant extra nodal spread of thedisease.
出处
《中华放射肿瘤学杂志》
CSCD
1994年第2期97-100,144,共5页
Chinese Journal of Radiation Oncology
