摘要
我们应用行为畸胎学的方法，建立了对雄性昆明种小鼠进行小剂量慢性醋酸铅染毒的动物模型。染毒剂量为１０００ｍｇ／１、５００ｍｇ／１、５０ｍｇ／１醋酸铅水溶液。染毒时间为５０天。染毒方式为自由饮用。观察其仔鼠的行为功能改变。结果发现：５００ｍｇ／Ｌ组（血铅■＝３８．０７７ ｇ／ｄ１）和１０００ｍｇ／Ｌ组（血铅■＝６１．０５６ ｇ／ｄ１）雄性小鼠精子畸形率明显高于正常对照组，但其仔代的行为功能除个别指标（平面翻正反射）外，无明显改变。提示，本实验条件下，铅对仔鼠行为功能的影响与雄性亲代接触铅关系不大。
Male Kuen-Ming mice were administrated at dose of 1000mg' 500mg and 50mg/L for 50days. The changes of the behavioral fuction of the litters were observed. The results showedthat the frequency of sperm malformation in the group (500mg/L and 1000mg/L ) were significantly higher than that of control, but no behavioral changes were found in the offspringsexcept the index of surface righting. The fact exhibited that under experimental condition therelationship between the male parent exposed to lead and the progeny behavioral funcfion areohs ons e.
出处
《毒理学杂志》
CAS
CSCD
1994年第S1期7-9,共3页
Journal of Toxicology
关键词
铅
雄性小鼠
仔代
行为功能
Lead
male mouse
behavioral
offspring.
