摘要
对５８例高血压患者和３４例正常人的血小板聚集功能进行比较研究，发现高血压Ⅱ期患者（３５例）的血小板最大聚集强度（Ｐｔｍａｘ）、聚集曲线坡度（ＰｔＨ）和聚集速率（ＰｔＫ）与正常人相比显著升高（Ｐ＜０．０１）而心功能却明显降低（Ｐ＜０．０１）。相关分析表明，Ｐｔｍａｘ，ＰｔＨ，ＰｔＫ和每搏输出量（ＳＶ）呈负相关（ｒ＝－０．０６，Ｐ＜０．０１；ｒ＝－０．５４，Ｐ＜０．０５；ｒ＝－０．５７，Ｐ＜０．０１），和射血前期／射血期比值（（ＰＥＰ／ＬＶＥＴ）呈正相关（ｒ＝０．６２，Ｐ＜０．０１；ｒ＝０．４８，Ｐ＜０．０５；ｒ＝０．５５．Ｐ＜０．０５）；而高血压Ⅰ期患者（２３例）的血小板聚集性和心缩功能与正常人相近（Ｐ＞０．０５）。提示高血压的不同阶段，血小板聚集性的改变可能对其病情的发展起重要作用。
PleteIet aggregation was evaluated in 58 cases with hypertension. The results showed that activity of platelet aggregation was significantly increased while cardiac systolic function was decreased (P<0.01) in phase Ⅱ hypertension compared with the control group,Pt max,Pt H ,Pt K were negatively corerlated with SV (r=-0.06,P<0.01;r=-0.05,P<0.01;r=-0.57,P<0.01,respectivly) and were positively correlated with PEP/LVET (r=0.62 ,P<0.01; r=0.48,P<0.05;r=0.54,P<0.05,respectively).Anormal platelet aggregation and cardiac systolic function was found in patients with phase Ⅰ hypertension.The results suggested that alteration of platelet aggregation may play a role in the the development of hypertension.
出处
《中华高血压杂志》
CAS
CSCD
1994年第4期248-249,共2页
Chinese Journal of Hypertension
关键词
血小板聚集
高血压
心功能
platelet aggregation
hypertension
cardiac function
