摘要
对２６例流行性出血热（ＥＨＦ）患者测定了肾小球滤过率（ＧＦＲ）和有效肾血浆流量（ＥＲＰＦ），并以１８名健康人作对照。结果显示ＥＨＦ患者从发热后期至多尿期ＧＦＲ与ＥＲＰＦ均显著下降，重型较中型下降更著。用放免法同步检测了血浆血管紧张素一Ⅱ（ＡＴ一Ⅱ）、血栓素Ｂ２（ＴＸＢ２）和６一酮一前列腺素Ｆ＿１α（６一Ｋ一ＰＧＦ＿１α），发现病程前三期ＡＴ一Ⅱ和ＴＸＢ２显著增高，６一Ｋ一ＰＧＦ＿１α变化不大或稍微降低，致ＴＸＢ２／６一Ｋ一ＰＧＦ＿１α比值明显上升。我们认为有效血容量降低和若干体液因子的变化是导致ＧＦＲ与ＥＲＰＦ下降的主要原因，而肾脏血液动力学变化又是造成ＥＨＦ肾功能损害诸因素中一个重要因素。
he role of renal
hernodynamics and humoralfactors in the pathogenesis of epidemic hemorrhagicfever (EHF)
were studied during the period betweenJanuary 1991 andMarch 1992. Glomerular filtrationrate
(GFR) and effective renal plasma flow (ERPF)were dynamically examined by ECT apparatus in
26cases with EHF, and 18 healthy subjects as controls.It was found that the values of GFR and
ERPF inEHF patients were much lower than that in norinalsublects (104. 2±21. 9 and 580±
77ml/min respec-tively) , and they were even lower in severe type thanin moderate type.
Plasma angiotensin-Ⅱ AT-Ⅱ) ,thromboxane B2 (TXB2) and 6- Keto- prostaglandinFi. (6-K-PGF1
α) were simultaneously detected byradioimmunoassay at all stages. The results indicatedthat
in the first three phases plasrna AT-Ⅱ andTXB2 were much higher than normal levels,
whileplasma 6-KPGF1α was only slightly decreased orno change, the ratio of TXB2 to 6- K-
PGF1α wasthus strikingly increased. We conclude that the de-creased effective blood volume
and the changes of va-soactive substances might be responsible for the de-cline of GFR and
ERPF and also for the abnormal re-nal function.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
1994年第5期274-277,323,共5页
Chinese Journal of Nephrology
