摘要
给小鼠腹腔注射除莠剂2、4-二氯苯氧乙酸(2、4-D)能够引起血清磷酸肌酸激酶(SCRK)升高,同时肌肉磷酸肌酸激酶(MCPK)下降。用豚鼠后肢肌肉匀浆加氢氧化铝足跖部皮下注射及腹腔注射百日咳菌苗的方法可以诱发大鼠SCPK增高,后肢肌肉出现变性坏死。灵芝孢子粉对注射2、4-D小鼠的SCPK升高和MCPK的降低有纠正作用。对大鼠过敏性肌炎引起的SCPK增高也有降低作用,并可减轻后肢肌细胞变性及坏死等病理改变。本研究结果为解释灵芝孢子粉注射液(商品名肌生注射液)治疗多发性肌炎、皮肌炎等肌肉病提供了病理学依据。
The effect of the water soluble preparation of the spores of Ganoderma Lucidum on chemical myositis induced by 2、4-dichlorophenoxyacetic acid (2, 4-D) in mice and on allergic myositis induced by immunization of limbs muscle homogenate of guinea-pig in rats was investigated. Subcutaneous injection of 2, 4-D (200mg/kg) to mice induced elevation of creatine phosphate kinase (CPK) in serum and decreasing of CPK in muscle of limbs. Prior injection (ip) of the water soluble preparation of the spores inhibited the changes of CPK in both serum and muscle in mice injected with 2, 4-D. But the same dose of the preparation of the spores had on influence on serum CPK in normal mice.
The muscle lesions of hind legs and serum CPK of experimentally allergic myositis were markedly reduced by simultaneous treatment of the preparation of the spores in rats. The results show that the preparation of the spores of Ganoderma Lucidum protects skeleton muscle from damages induced by the chemical toxicant and by immunization of the heterogeneous muscle homogenate in animals.
出处
《中药药理与临床》
CAS
CSCD
1993年第2期23-26,共4页
Pharmacology and Clinics of Chinese Materia Medica
关键词
灵芝孢子粉
2、4-二氯苯氧乙酸
磷酸肌酸激酶
过敏性肌炎
spores of Ganoderma Lucidum, 2、 4-dichlorophenoxyacetic acid, crea-tine phosphate kinase, allergic myositis
