摘要
本文对37例早产儿呼吸暂停分别用氨茶碱和咖啡因治疗作临床疗效分析,结果氮茶碱组的症状消失时间和疗程均短于咖啡因组(P<0.05),提示前者疗效优于后者,与国外文献报道不完全一致。药物血浓度监测证明氨茶碱用量适宜,咖啡因维持量偏大,血浓度超出有效范围,建议调整维持量,咖啡因碱2.5mg/kg·d口服,枸橼酸(或安钠)咖咖啡因5mg/kg·d静注,每月1次。
In order to compare the clinical therapeutc efficacy between aminophylline and coffein on premature apnea, 37 cases treated respec- tively were prospectively studied. The serum concentration of coffein and theophylline were monitored in partial cases. The results showed that the disappeared time of apnea and the therapeutic duration in amionphylline group (25 cases) were significantly shorter than that of coffein group (12 cases) (P<0.05). The average serum concentration of theophylline was normal within the effective range, but the average serum concentration of coffein during using maintenance dose was more over than the effective range. The adjustable coffein maintenance dose was suggested.
出处
《中国新生儿科杂志》
CAS
1993年第1期5-7,44-45,共5页
Chinese Journal of Neonatology
