摘要
报道国产氯米帕明(男21例,女14例,年龄83±11yr)和阿米替林(男16例,女19例,年龄33±12yr)治疗70例抑郁症的对照试验。1wk内加至150-250mg/d共4wk。结果显示抗抑郁疗效2药间无显著差异。汉密顿抑郁量表总分的减分氯米帕明组大于阿米替林组(分别为29±9,24±13,P<0.05)。2药主要副作用为口干、便秘、心悸、头晕等抗胆碱能作用,氯米帕明副作用略轻于阿米替林。
This paper reports a control study of clomipramine (M 21, F 14, age 33±11 yr) and amitriptyline (M 16, F 19, age 33±12 yr) for treatment on seventy depressive patients. By gradual increase of the dose to 150-250 mg/d within 1 wk for. 4 wk, the results showed that clomipramine had better antidepressive efficacy than amitriptyline, but without statistical significance. The decrease of HDS total scores of clomipramine and amitriptyline were 29±9 and 24±13 respectively, P<0.05. The common side effects of both drugs are anticholinergic effects, and clomipramine has lesser adverse reactions than amitriptyline.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
1991年第6期322-324,共3页
Chinese Journal of New Drugs and Clinical Remedies
