摘要
目的:探讨尿肝型脂肪酸结合蛋白(L-FABP)在重症患者急性肾损伤(AKI)中的早期诊断价值。方法:以我院收治的危重症患者为观察对象,按照阿姆斯特丹AKI诊断标准,将5d内符合诊断标准的AKI患者纳入AKI组(12例),对照组(12例)由匹配的非AKI患者构成。每24h收集尿标本,持续5d。ELISA法检测尿L-FABP水平。以受试者工作特征曲线评价L-FABP对AKI的诊断作用。结果:与AKI诊断前3d比较,AKI诊断前2d及1d患者尿L-FABP均明显增高(P均<0.05),但尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG)及血肌酐(Scr)无明显改变(P均>0.05);观察期间对照组尿L-FABP、NAG、Scr均无明显变化(P均>0.05)。AKI诊断前3d尿L-FABP、NAG、Scr对AKI均无诊断作用;AKI诊断前2d及1d尿L-FABP对AKI具有早期诊断作用,而NAG、Scr无早期诊断作用。结论:尿L-FABP对重症患者AKI具有较高的敏感性和特异性,可能具有AKI早期诊断价值。
Objective： To investigate the value of urinary liver-type fatty acid binding proteins（L-FABP） in the early diagnosis of acute kidney injury（AKI） in critically ill patients.Methods： Critically ill patients were divided into the AKI group（n=12） and non-AKI group（n=12）.Blood and urinary samples were collected daily for five days.The samples were used to determine serum creatinine（Scr）,N-acetyl-β-D-glucosaminidase（NAG）,as well as urinary L-FABP.Standard statistic analysis was used along with receiver operating characteristic curve analysis to evaluate the diagnose value.Results： There were no significant differences in clinical parameters between non-AKI（n=14） and AKI（n=12） groups.As compared with the levels obtained three days before the diagnosis of AKI,the urinary L-FABP levels in the AKI group increased significantly（P0.05）,while Scr and NAG levels had no changes two days or one day prior to the diagnosis of AKI（all P0.05）.The levels of urinary L-FABP,Scr and NAG had no significant changes in the control group（all P0.05）.Conclusion： Urinary L-FABP appears to be a sensitive and specific marker earlier than Scr,which may be a good biomarker for early diagnosis of AKI in critically ill patients.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2011年第6期793-795,共3页
Medical Journal of Wuhan University
关键词
肝型脂肪酸结合蛋白
急性肾损伤
早期诊断
Acute Kidney Injury
Liver-Type Fatty Acid Binding Proteins
Early Diagnosis
