摘要
目的探讨磁共振弥散加权成像（DwI）及表观弥散系数（ADC）在鉴别前列腺良、恶性肿瘤中的价值。方法对经病理或穿刺活检证实的22例前列腺癌、17例良性前列腺增生患者以及20例健康志愿者行前列腺平扫MRI、DWI和增强MRI检查，并在工作站测量感兴趣区的ADC，对前列腺癌、良性前列腺增生和正常前列腺的ADC进行统计学分析。结果前列腺癌、良性前列腺增生、正常前列腺在中央腺体和外周带的ADC分别为1．08±0．23、1．43±0．27、1．51±O．26和1．26±0．47、1．72±0．40、1．75±0．28，前列腺癌的ADC明显低于良性前列腺增生和正常前列腺，差异有统计学意义（P〈0．05），而良性前列腺增生与正常前列腺比较差异无统计学意义（P〉0．05）。以前列腺中央腺体和外周带的ADC分别是1．30和1．60为阈值来鉴别前列腺良、恶性肿瘤，具有较高的灵敏度和特异度。结论DWI及ADC的应用大大提高了MRI对前列腺良、恶性肿瘤的诊断和鉴别诊断能力。
Objective To study the value of MR diffusion weighted imaging （DWI） and apparent diffusion coefficient（ADC） in differentiating benign and malignant lesions of prostate. Methods Twenty-two patients with prostate cancer and 17 patients with benign prostatic hyperplasia confirmed by pathology or biopsy, and 20 healthy volunteers were underwent prostate plain MRI, DWI and enhanced MRI, and measuring the value of ADC in the regions of interest in the workstation, and the ADC values of prostate cancer,benign prostatic hyperplasia, normal prostate were analyzed statistically. Results The ADC of prostate cancer,benign prostatic hyperplasia, normal prostate in central gland and peripheral zone were 1.08 ±0.23,1.43 ±0.27,1.51± 0.26 and 1.26 ±0.47,1.72 ±0.40,1.75 ±0.28,respectively, the ADC of prostate cancer was significantly lower than that of benign prostatic hyperplasia and normal prostate, and there was significant difference （P 〈 0.05 ）, but there was no significant difference between benign prostatic hyperplasia and normal prostate （P 〉0.05）. Looking the ADC was 1.30 and 1.60 in central gland and peripheral zone as the threshold to distinguish benign and malignant lesions of prostate, had high sensitivity and specificity. Conclusion The application of DWI combined with ADC, has improved the capability of diagnosis and differential diagnosis in benign and malignant lesions of prostate greatly.
出处
《中国医师进修杂志》
2011年第32期28-31,共4页
Chinese Journal of Postgraduates of Medicine
关键词
前列腺肿瘤
前列腺增生
磁共振成像
弥散
Prostatic neoplasms
Prostatic hyperplasia
Diffusion magnetic resonance imaging
