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辛伐他汀对大鼠急性脊髓损伤后Toll样受体4／核因子-kB及白细胞介素-1β表达的影响 被引量：3

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摘要 脊髓损伤（SCI）是一种发病率及致残率都很高的疾病。有研究结果表明辛伐他汀可抑制脊髓损伤后炎症因子释放，减少损伤区神经细胞死亡，有脊髓保护作用，但其具体保护机制尚不明了。我们通过观察脊髓损伤后Toll样受体4（TLR4）、
作者 孔杰 梁维邦 倪红斌 王斌 徐武 吴俊 金伟
机构地区 南京大学附属鼓楼医院神经外科
出处 《中华实验外科杂志》 CAS CSCD 北大核心 2011年第12期2261-2261,共1页 Chinese Journal of Experimental Surgery
关键词 TOLL样受体4 急性脊髓损伤 白细胞介素-1Β 辛伐他汀 核因子-KB 大鼠 神经细胞死亡 炎症因子
分类号 R651 [医药卫生—外科学]
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  • 1Ehrlich LC, Peterson PK, Hu S. Interleukin (IL)-1beta -mediated apoptosis of human astrocytes. Neuroreport, 1999, 10:1849-1852.
  • 2Takahashi JL, Giuliani F, Power C, et al. Interleukin-1beta promotes oligodendrocyte death through glutamate excitotoxicity. Ann Neurol,2003, 53: 588-595.
  • 3Hernandez-Rodriguez J, Segarra M, Vilardell C, et al. Tissue production of pro-inflammatory cytokines (IL-1β, TNF-α and IL-6) correlates with the intensity of the systemic inflammatory response and with corticosteroid requirements in giant-cell arteritis. Rheumatology (Oxford),2004, 43: 294-301.
  • 4Willis BH, Carden DL, Sadasivan KK, et al. Effect of femoral fracture and intramedullary fixation on lung capillary leak. J trauma, 1999, 46:687-692.
  • 5Liu XZ, Xu XM, Hu R, et al. Neuronal and glial apoptosis after traumatic spinal cord injury. J Neurosci, 1997, 17 : 5395-5406.
  • 6Goessl G, Sauter, Miller K. Nitric oxide donors in treatment of spinal cord injury. Lancet, 2001, 358:1460-1461.
  • 7Lang-Lazddunski L, Heurteaux C, Mignon A, et al. Ischemic spinal cord injury induced by aortic cross-clamping: prevention by riluzole. Eur J Cardiothorac Surg, 2000, 18 : 174-181.
  • 8Wada S, Yone K, lshidou Y, et al. Apoptosis following spinal cord injury in rats and prevention effect of N-methyl-D-aspartate receptor antagonist. J Neurosurg, 1999, 91 : 98-104.
  • 9刘清行,金惠铭.TNFα对大鼠肺微血管内皮细胞NO的产生及NOS mRNA表达的影响[J].上海医科大学学报,1999,26(1):4-7. 被引量：17
  • 10彭昊,刘世清,周华,郭卫春,任岳.白细胞介素-10对大鼠脊髓损伤后神经细胞凋亡的影响[J].中华实验外科杂志,2003,20(12):1125-1126. 被引量：3

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  • 1Ng CSH,Wan S, Yim APC, et al. Pulmonary dysfunction after cardiac surgery. Chest,2002,121:1269-1277.
  • 2Herzog EL, Brody AR, Colby TV, et al. Knows and unknowns of the alveolus. Proc Am Thorac Soe ,2008,5:778-782.
  • 3Harris JB, Chang LY, Crapo JD. Rat lung alveolar type I epithelial ceil injury and response to hyperoxia. Am J Respir Cell Mol Biol, 1991,4 : 115-125.
  • 4Naidu BV,Woolley SM, Farivar AS, et al. Simvastatin ameliorates in- jury in an experimental model of lung ischemia-reperfusion. J Thorac Cardiovasc Surg ,2003,126:482-489.
  • 5Takahashi S, Nakamura H, Seki M,et al. Reversal of elastase-induced pulmonary emphysema and promotion of alveolar epithelial cell prolif- eration by simvastatin in mice. Am J Physiol Lung Cell Mol Physiol, 2008,294 : 882 -890.
  • 6Slack JM,Tosh D. Transdifferentiation and metaplasia-switching cell types. Curr Opin Genet Dev,2001,11:581-586.
  • 7Clegg GR, Tyrrell C, McKechnie SR, et al. Coexpression of RTI40 with alveolar epithelial type II cell proteins in lungs following injury: identification of alveolar intermediate cell types. Am J Physiol,2005, 289 : 382-390.
  • 8Mason RJ, Kalina M, Nielsen LD, et al. Surfactant Protein C Expres- sion in Urethane-Induced Murine Pulmonary Tumors. Am J Patho, 2000,156 : 175-182.
  • 9Newman GR,Campbell L,von Ruhland C,et al. Caveolin and its cel- lular and subcellular immunolocalisation in lung alveolar epithelium: implications for alveolar epithelial type I cell function. Cell Tissue Res, 1999,295 : 111-120.
  • 10Li X,Xu B. HMG-CoA reductase inhibitor regulates endothelial pro- genitor function through the phosphatidylinositol3 ' -kinase/AKT sig- nal transduction pathway. Appl Biochem Biotechnol,2009,157:545- 553.

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中华实验外科杂志
2011年 第12期

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