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人源抗菌肽LL-37在创伤修复中的研究进展 被引量：5

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摘要 随着全球经济的快速发展,社会冲突、交通事故以及自然灾害的发生越来越频繁,创伤发病率增高,给个人和社会都造成巨大的负担.世界卫生组织调查统计,全球每年因创伤致死者约500万余人,占全部死亡原因的10%.机体的创伤愈合是一个由多种细胞及分子参与的复杂的生理过程,包括炎症期,增殖期,以及组织重塑期[1].LL-37作为关键的信号分子之一,与各类细胞及各种因子相互作用,协调达到平衡状态,有助于创伤修复.研究发现,人源抗菌肽LL-37能抗菌、调节炎症反应[2-4]、促进新生血管发生[5]及上皮再生[6]等,在创伤修复过程中发挥重要作用.本文就LL-37在创伤修复中的研究进展作一总结.
作者 丁静 沈娟 朱家勇 金小宝
机构地区 广东药学院药用生物活性物质研究所
出处 《广东医学》 CAS CSCD 北大核心 2011年第18期2472-2475,共4页 Guangdong Medical Journal
基金 广州市科技计划项目(编号:2010J-E411)
关键词 抗菌肽LL-37 创伤修复 人源 世界卫生组织 新生血管发生 信号分子 自然灾害 交通事故
分类号 R392.11 [医药卫生—免疫学]
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参考文献38

  • 1FALANGA V. Wound healing and its impairment in the diabetic foot[J]. The Lancet, 2005, 366(9498) : 1736 -1743.
  • 2NIYONSABA F, NAGAOKA I, OGAWA H. Human defensins and cathelicidins in the skin: beyond direct antimicrobial proper- ties[J]. Crit Rev Immunol, 2006, 26(6): 545-576.
  • 3NIYONSABA F, OGAWA H. Protective roles of the skin against infection : implication of naturally occurring human antimicrobial a- gents beta - defensins, cathelicidin LL - 37 and lysozyme [ J ]. J Dermatol Sci, 2005, 40(3) : 157-168.
  • 4YOSHIKA M, FUKUISHI N, KUBO Y, et al. Human Catheliei- din CAP18/LL- 37 changes mast cell funtion toward innate immu- nity[J]. Biol Pharm Bull, 2008, 31(2) : 212 -216.
  • 5KOCZULLA R, DEGENFELD G, KUPATr C, et al. An angio- genic role for the human peptide antibiotic LL - 37/hCAP - 18 [J~. J Clin Invest, 2003, 111(11) : 1665 -1672.
  • 6HEILBORN J D, NILSSON M F, KRATZ G, et al. The cathelici- din anti - microbial peptide LL - 37 is involved in re - epithelial- ization of human skin wounds and is lacking in chronic ulcer epi- thelium[ J ]. J Invest Dermatol, 2003, 120 (10) : 379 - 389.
  • 7高云,黄宇烽.肽抗生素LL-37的研究进展[J].医学研究生学报,2004,17(3):276-277. 被引量：2
  • 8SORENSEN O E, FOLLIN P, JOHNSEN A H, et al. Human cathelicidin, hCAP - 18, is processed to the antimicrobial peptide LL- 37 by extracellular cleavage with proteinase 3 [ J ]. Blood, 2001, 97(12) : 3951 -3959.
  • 9STEINSTRAESSER L, KOEHLER T, JACOBSEN F, et al. Host defense peptides in wound healing[ J]. Mol Med, 2008, 14(7/8): 528 -537.
  • 10MENDEZ SAMPERIO P. The human cathelicidin hCAP18/LL - 37 : a muhifunetional peptide involved in mycobacterial infections [J]. Peptides, 2010, 31(9) : ]791 -1798.

二级参考文献43

  • 1吴金京,丁艳,尹湘毅,张国琇.抗生素的临床应用与医院感染分析[J].医学研究生学报,2001,14(4):336-337. 被引量：6
  • 2[1]Sorensen O, Arnljots K, Cowland JB et al. The human antibacterial cathelicidin, hCAP-18, is synthesized in myelocytes and metamyelocytes and localized to specific granules in neutrophils[J]. Blood, 1997, 90(7): 2796-2803.
  • 3[2]Agerberth B, Gunne H, Odeberg J et al. FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis[J]. Proc Natl Acad Sci USA , 1995, 92(1): 195-199.
  • 4[3]Frohm NM, Sandstedt B, Sorensen O et al. The human cationic antimicrobial protein (hCAP18), a peptide antibiotic, is widely expressed in human squamous epithelia and colocalizes with interleukin-6[J]. Infect Immun, 1999 , 67(5): 2561-2566.
  • 5[4]Nizet V, Ohtake T, Lauth X et al. Innate antimicrobial peptide protects the skin from invasive bacterial infection[J].Nature, 2001, 414(6862): 454-457.
  • 6[5]Nagaoka I, Hirota S, Niyonsaba F et al. Cathelicidin family of antibacterial peptides CAP18 and CAP11 inhibit the expression of TNF-alpha by blocking the binding of LPS to CD14+ cells[J]. J Immunol, 2001, 167(6): 3329-3338.
  • 7[6]Wang Y, Agerberth B, Lothgren A et al. Apolipoprotein A-Ⅰ binds and inhibits the human antibacterial/cytotoxic peptide LL-37[J]. J Biol Chem, 1998, 273(50): 33115-33118.
  • 8[7]De Yang, Chen Q, Schmidt AP et al. LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells[J]. J Exp Med, 2000, 192(7): 1069-1074.
  • 9[8]Koczulla R, Degenfeld G, Kupatt C et al. An angiogenic role for the human peptide antibiotic LL-37/hCAP-18 [J]. J Clin Invest, 2003, 111(11): 1665-1672.
  • 10[9]Martin RC, Duquenne C, Treton D et al. SOB3, a human sperm protein involved in zona pellucida binding: physiological and biochemical analysis, purification[J]. Mol Reprod Dev, 1998, 49(3): 286-297.

共引文献7

同被引文献95

  • 1窦宇红,吴雄君,唐银.黏质物在凝固酶阴性葡萄球菌生物膜耐药机制中的作用[J].中华医院感染学杂志,2006,16(10):1089-1092. 被引量：19
  • 2Vogel HJ,Schibli DJ,Jing W. Towards a structurefunction analysis of bovine lactoferricin and related tryptophanand arginine-containing peptides[J].{H}Biochemistry and Cell Biology-Biochimie et Biologie Cellulaire,2002,(1):49-63.
  • 3Takayama Y,Aoki R. Roles of lactoferrin on skin wound healing[J].{H}Biochemistry and Cell Biology-Biochimie et Biologie Cellulaire,2012,(3):497-503.
  • 4Vandamme D, Landuyt B, Luyten W, Schoofs L. A comprehensive summary of LL-37, the facto- tum human cathelicidin peptide. Cell Immunol 2012; 280:22-35 [PMID 23246832 DOI: 10.1016/ j.cellimm.2012.11.009].
  • 5Wu WK, Wang G, Coffelt SB, Betancourt AM, Lee CW, Fan D, Wu K, Yu J, Sung JJ, Cho CH. Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications. Int J Cancer 2010; 127:1741-1747 [PMID: 20521250 DOI: 10.1002/ijc.25489].
  • 6Bucki R, Leszczyfiska K, Namiot A, Sokoiowski W. Cathelicidin LL-37: a multitask antimicrobial pep- tide. Arch Immunol Ther Exp (Warsz) 2010; 58:15-25 [PMID: 20049649 DOI: 10.1107/s00005-009-0057-2].
  • 7Porcelli F, Verardi R, Shi L, Henzler-Wildman KA, Ramamoorthy A, Veglia G. NMR structure of the cathelicidin-derived human antimicrobial peptide LL-37 in dodecylphosphocholine micelles. Biochem- istry 2008; 47:5565-5572 [PMID: 18439024 DOI: 10.1021/bi702036s].
  • 8Yang D, de la Rosa G, Tewary P, Oppenheim JJ. Alarmins link neutrophils and dendritic cells. Trends Immunol 2009; 30:531-537 [PMID: 19699678 DOI: 10.1016/j.it.2009.07.004].
  • 9Gallo RL, Hooper LV. Epithelial antimicrobial de- fence of the skin and intestine. Nat Rev Immunol 2012; 12:503-516 [PMID: 22728527 DOI: 10.1038/ nri3228].
  • 10Steinstraesser L, Koehler T, Jacobsen F, Daigeler A,Goertz O, Langer S, Kesting M, Steinau H, Eriksson E, Hirsch T. Host defense peptides in wound heal- ing. Mol Med 2008; 14:528-537 [PMID: 18385817].

引证文献5

二级引证文献31

广东医学
2011年 第18期

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