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膝骨性关节炎滑液中骨桥蛋白的表达及临床意义 被引量:6

Expression and clinical significance of OPN in synovial fluid of patients with knee osteoarthritis
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摘要 目的:探讨骨桥蛋白(osteopontin,OPN)在膝骨性关节炎关节滑液中的表达及其临床意义。方法:检测膝骨性关节炎(osteoarthritis,OA)患者和创伤骨折患者膝关节滑液中OPN的含量,并加以比较结果:OA组关节滑液中OPN含量为(3978.7±459.1)ng·L^(-1),对照组关节滑液中OPN含量为(874.2±259.3)ng·L^(-1),两组数值经统计学分析,差异有统计学意义(P<0.05)。两组关节液中OPN含量与OA的病变严重程度(关节镜下分级),经Spearman等级相关检验,两者呈正相关(P<0.05)。结论:OPN与膝骨性关节炎的发病和发展有关。 Objective:To investigate the expression and clinical significance of osteopontin(OPN) in in synovial fluid of patients with knee osteoarthritis. Methods:Content of OPN in synovial fluid was measured and compared from the patients with knee osteoarthritis and with fracture. Results:Synovial fluid OPN in OA group was 3978.7 ±459.1 ng ·L-1 ,874. 2±259.31 ng·L-1 in the fracture group. There was significant difference between the 2 groups by statistical analysis( P 〈 0.05 ). Subsequent analysis showed that the OPN level in synovial fluid significantly was correlated with severity of disease ( P 〈 0.05 ) by Spearman rank correlation method. Conclusion : The data suggest that expression of OPN in synovial fluid is related to progressive joint damage.
出处 《中医正骨》 2011年第11期7-9,共3页 The Journal of Traditional Chinese Orthopedics and Traumatology
关键词 骨关节炎 骨桥蛋白 osteoarthritis, knee osteopontin
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