摘要
目的:了解肾小球疾病尿蛋白肌酐比(UPCR)与24h尿蛋白(U-TP)定量的相关性及其相关性的影响因素。方法:选取125例低白蛋白血症肾小球疾病患者和20例健康对照者采用等级相关分析判断UPCR与24hU-TP定量的相关性;按性别、年龄、肾脏功能(根据Ccr)、血浆ALB浓度,24hU-TP定量、疾病种类进行分层,了解其对相关性的影响,同时采用ROC曲线判断UPCR的界点值。结果:病例组与对照组UPCR与24hU-TP定量的相关系数(r)分别为0.825、0.992;性别、年龄、肾功能(Ccr>10ml/min)、血浆ALB浓度,疾病种类对其相关性无影响,但U-TP定量影响其相关性,当24hU-TP定量≥5.0g时,r=0.338(P=0.134);通过ROC曲线得到当24hU-TP定量分别为1g和3.5g时UPCR值分别为1.05g/g和3.518g/g。结论:肾小球疾病患者及健康对照者UPCR与24hU-TP定量均有显著的正相关性;其相关性不受性别、年龄、肾功能(Ccr>10ml/min)、血浆ALB浓度,疾病种类的影响,但U-TP定量影响其相关性,当24hU-TP定量≥5.0g时,其不具有相关性;通过ROC曲线得到当UPCR大于3.5g/g可考虑为大量蛋白尿协助临床诊断。
Objective：To evaluate the correlation between UPCR and 24-hour U-TP in the glomerular disease and its influenced factors.Methods： 125 cases of glomerular diseases with hypoalbuminemia and 20 healthy voluntors were tested the plasma ALB concentration,U-TP concentration,blood and urine creatinine concentration,calculate UPCR.By gender,age,renal function（by Ccr）,plasma ALB concentration,24-hour U-TP quantitation,the types of diseases stratified respectively.Calculating with the SPSS then judging the correlation,those influencing factor,meanwhile introduce of ROC curve to judge cutoff values.Result： 125 cases of glomerular diseases with hypoalbuminemia and 20 healthy voluntors had significant correlation,r was 0.992,0.825 respectively;The correlation had not been influenced by gender,age,plasma ALB concentration,Ccr,the types of diseases;24-hour U-TP quantitation impacts the correlation,when U-TP≥5.0g/24h,there was no correlation;Cutoff values of UPCR for screening U-TP of 1g/24h and 3.5g/24h respectively was 1.05g/g and 3.518g/g by ROC curve.Conclusion： There is significantly positive correlation between UPCR and 24-hour U-TP in the glomerular diseases with hypoalbuminemia;The correlation has not been influenced by gender,age,plasma ALB concentration,Ccr（10ml/min）,the types of diseases;24-hour U-TP quantitation impacts the correlation,when U-TP≥5.0g/24h,there is no correlation;When UPCR is more than 3.518g/g,it suggests that losing large proteinuria.
出处
《陕西医学杂志》
CAS
2011年第11期1477-1480,共4页
Shaanxi Medical Journal
关键词
肾疾病/病理生理学
低蛋白血症
蛋白肌肝
@24h尿蛋白
Kidney diseases/physiopathology Hypoproteinemia @Protein to crecotinine @ 24h urinary protein
