摘要
目的观察老年晚期乳腺癌应用卡培他滨单药方案化疗的疗效与毒性。方法 65岁以上晚期老年乳腺癌患者30例,给予卡培他滨2000mg/(m2·d),服2周停1周为1个疗程。所有患者均评估毒性,至少用过2个周期的患者评估疗效。结果 30例患者共完成105个疗程,中位化疗疗程数为3.5个。总有效率为36.7%,临床受益率为66.7%,中位疾病进展时间(TTP)7.9个月,中位生存期14个月。Ⅲ、Ⅳ度不良反应有:Ⅲ度白细胞下降6例(20%),Ⅲ度手足综合征5例(17%),Ⅲ度腹泻2例(7%),Ⅳ度恶心、呕吐2例(7%)。结论初步研究结果显示卡培他滨单药治疗老年晚期乳腺癌疗效较好,毒性可耐受。
Objective To evaluate the safety and efficacy of capecitabine alone chemotherapy for advanced breast cancer in elderly.Methods Thirty elderly （over 65 years old） patients with advanced breast cancer was received oral capecitabine 2000mg/m^2/day,on day 1 to 14 every 21 days.All Patients were evaluated for toxicity and who had received at least two course of chemotherapy for efficacy.Results A total of 105 cycles were given in all patients and with a median of 3.5 cycles per patient.The overall response rate （RR） was 36.7%.This gave a clinical benefit （RR ＋ SD） of 67 %.Median time to progression was 7.9 months,and median overall survival was 14 months.Leucopenia grade Ⅲwas observed in 6 patients （20%）,Grade Ⅲ handfoot syndrome was observed in 5 patient s （17 %）,2 patients（7%） experienced grade Ⅳ nausea and vomiting,while another experienced grade Ⅲ diarrhea.No other grade Ⅲor Ⅳtoxicity was observed.Conclusion Capecitabine alone is safe and effective for advanced elderly breast cancer.
出处
《临床合理用药杂志》
2011年第10X期48-49,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
卡培他滨
乳腺肿瘤
老年
药物疗法
Capecitabine
Breast neopalsms
Elder
Drug therapy
