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乳腺癌微血管生成及nm23表达的临床意义 被引量：2

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摘要 目的探讨乳腺癌组织中微血管生成及nm23表达的关系及其临床意义。方法应用SP免疫组织化学染色方法 ,以CD3 4单克隆抗体标记6 5例乳腺癌肿瘤组织中微血管,计数微血管密度(MVD),同时检测肿瘤组织中nm23的表达,分析乳腺癌组织血管生成和nm23的表达及两者与肿瘤生物学行为的关系。结果全部肿瘤标本有不同程度的微血管生成,并表现出明显的异质性。MVD计数为3～33个/400倍视野(平均11.6±7.0),nm23阳性表达率为81.5%。MVD与nm23的表达呈负相关(P=0.011),且两者分别与患者年龄、肿瘤大小无明显关系,而与肿瘤淋巴转移有关(P=0.0 1 4,0.0 0 5)。nm2 3的表达与肿瘤临床分期有关(P=0.0 3 8)。结论乳腺癌肿瘤组织中的微血管生成促进了淋巴转移,而nm23的表达可抑制淋巴转移;联合检测MVD及nm23对评估肿瘤淋巴转移风险具有一定的临床意义,可预测患者的预后。
作者 李洋 黄俊辉
机构地区 湖南省人民医院普外二科 中南大学湘雅医院肿瘤科
出处 《中国普通外科杂志》 CAS CSCD 北大核心 2011年第11期1268-1270,共3页 China Journal of General Surgery
关键词 乳腺肿瘤/病理学 微血管密度 CD34 NM23
分类号 R737.9 [医药卫生—肿瘤]
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参考文献11

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二级参考文献7

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共引文献116

同被引文献27

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二级引证文献15

中国普通外科杂志
2011年 第11期

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