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膀胱炎性肌纤维母细胞瘤的临床病理分析 被引量:4

Clinicopathologic Analysis of Inflammatory Myofibroblastic Tumor of the Urinary Bladder
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摘要 目的:探讨膀胱炎性肌纤维母细胞瘤的临床、病理和诊治方法及预后。方法:对2例膀胱炎性肌纤维母细胞瘤患者的临床资料、病理形态学和免疫组织化学染色进行观察;对2例患者进行随访观察。结果:病例1行膀胱部分切除术,病例2行全膀胱切除+盆腔淋巴结清扫术。组织学表现均为增生的梭形或长梭形肿瘤细胞囊状分布,间质小血管增生,伴淋巴细胞、嗜酸性粒细胞及浆细胞浸润。免疫组织化学染色结果:病例1为SMA(+),Vimentin(+),ALK(+)。病例2为SMA(+),CD68(+),Vimentin(+),CgA(+),ALK(-)。2例病例均不表达CK7、S-100、MyoDl、CK19、α-actin、EMA。2例患者均未见复发。结论:膀胱炎性肌纤维母细胞瘤是一种少见肿瘤,确诊主要依据组织病理学检查及免疫组织化学染色,应与横纹肌肉瘤、梭形细胞癌等鉴别,治疗以膀胱部分切除或经尿道切除为主。 Objective: To review the clinicopathologic features of inflammatory myofibroblastic tumor of the urinary bladder (IMTUB) and to discuss its diagnosis, treatment, and prognosis. Methods: The clinical data, light microscopy, and immunohistochemical results of two IMTUB cases were analyzed. Follow-up of the two patients was also conducted. Results: Partial cystectomy was per- formed on Case I. Total cystectomy plus pelvic lymphadenectomy was conducted on Case II. The post-operative pathological examination indicated that the sections exhibited spindle neoplastic cells and capillary proliferation, accompanied by infiltration of lympho- cytes, eosinophil cells, and plasma cells. Immunohistochemical staining of the Case I revealed smooth muscle actin ( SMA ) ( + ), Vi- mentin ( + ), and anaplastic lymphoma kinase ( + ). Immunohistochemical staining of the CaseⅡ showed SMA ( + ), CD68 ( + ), Vi- mentin ( + ), chromogranin A ( + ), and anaplastic lymphoma kinase (-). Tumor cells were negative for CK7, S-100, MyoD1, CK19, Actin, and EMA. Signs of recurrence were not found in the two cases. Conclusion: IMTUB is a rare tumor. Final diagnosis of the tumor depends mainly on histopathological examination and immunohistochemical staining. IMTUB should be differentiated from rhabdo- myosarcoma and other spindle-cell carcinomas. Partial cystectomy or transurethral resection is the main choice of treatment.
出处 《中国肿瘤临床》 CAS CSCD 北大核心 2011年第22期1400-1402,1407,共4页 Chinese Journal of Clinical Oncology
关键词 炎性肌纤维母细胞瘤 膀胱 诊断 治疗 Inflammatory myofibroblastic tumor Urinary bladder Diagnosis Therapy
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