摘要
AEG-1对肿瘤多种生物学特性均有促进作用,并与肿瘤血管生成密切相关。实验证实AEG-1过度表达的肿瘤部分新生血管较多,AEG-1也可以提高VEGF启动子的活性以及相关分子的表达水平。与AEG-1介导血管生成有关的分子包括PI3k/Akt、Tie2、Ang1、H-ras和HIF-1α等。在信号转导途径中最为重要的是PI3k/Akt信号通路,PI3k/Akt起到联系H-ras和AEG-1的作用,并介导由AEG-1引起的Ang1/Tie2下游靶位点的激活。NF-κB,H-ras/MEK在AEG-1介导的血管生成中也起到重要作用。
AEG-1 plays an important role in many biological characteristics of tumor and is closely correlated with tumor angiogenesis. Many experiments established that AEG-1 overexpression in tumor is positively correlated with angiogenesis. Simultaneously, it can also activate the promotor of VEGF and has an effect on the expression level of VEGF-related molecules, including PI3k/Akt, Tie2, Angl, H-ras and HIF-la. PI3k/Akt signal pathway is one of important pathways that contacts H-ras and AEG-1, and mediates the activation of Angl/Tie2. Furthermore, NF- κ B and H-ras/MEK also play a vital role in AEG-l-mediated angiogenesis.
出处
《分子诊断与治疗杂志》
2011年第6期416-419,共4页
Journal of Molecular Diagnostics and Therapy
基金
国家自然科学基金(30900650H1615)
广东省自然科学基金(9451008901002146)
