摘要
目的:观察纾萎方治疗慢性萎缩性胃炎(CAG)的胃黏膜病理改变及临床疗效。方法:采用随机与阳性对照药平行对照的方法,将189例CAG患者分为治疗1组(纾萎方)63例,治疗2组(纾萎方加减)64例,对照组(胃复春)62例。观察3组病理检查胃黏膜腺体萎缩、肠上皮化生(IM)、异型增生(ATP)及临床症状改善情况和幽门螺杆菌(Hp)感染的变化。结果:病理疗效:治疗1组总有效率73.02%,治疗2组总有效率73.44%,对照组51.61%(P<0.05);症候积分差变化:治疗组1组6.16±2.73,治疗2组5.08±4.86,对照组2.80±2.57(P<0.01)。治程和随访无CAG癌变发生。结论:纾萎方对CAG、IM及ATP有逆转作用,明显改善临床症状,显著提高CAG临床和病理综合疗效。
Objective：To observe the effect of Shuweifang on reversing pathological changes of gastric mucosa in patients with chronic atrophic gastritis（CAG）.Methods：One hundred and eighty-nine patients with CAG were randomly divided into 3 groups for parallel comparative study.Group I have 63 patients who were treated with Shuweifang and group II have 64 patients who were treated with Modified Shuweifang.Group three is the control group which has 62 patients treated with Weifuchun.Atrophy of glandular organ in gastric mucosa,intestinal metaplasia（IM）,atypical hyperplasia（ATP）,Helicobacter pyloric infection（Hp）and improvement of clinical symptoms were observed.Results：Pathological improvements were 73.02% for group I,73.44% for group II and 51.61% for control group（P〈0.05）;relieve of symptoms were 6.16±2.73 for group I,5.08±4.86 for group II and 2.80±2.57 for control group（P〈0.01）.There was no development of cancer in all the CAG cases during the treatment and follow-ups.Conclusions：Shuweifang has a significant effect on reversing CAG,IM and ATP in patients with CAG.It can relieve clinical symptoms and improve pathological changes of CAG.
出处
《辽宁中医药大学学报》
CAS
2011年第12期93-95,共3页
Journal of Liaoning University of Traditional Chinese Medicine
基金
上海市卫生局中医药科研基金课题
关键词
萎缩性胃炎
中医药疗法
纾萎方
Atrophic Gastrititis
traditional Chinese medicine
Suweifang
